The epidemiology of anencephaly and spina bifida in Izmir, Turkey, in the light of recent aetiological theories
Küçük Resim Yok
Tarih
1979
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Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The data from this study suggest that, in western Turkey, potato consumption and water hardness do not play a sigificant role in the aetiology of anencephaly and spina bifida (ASB). Several of the predictions of the fetus-fetus interaction theory are not supported. Other predictions could not be tested because of lack of information on the dizygotic (DZ) twinning rate. Twin data from this study, together with previous material containing explicit information on zygosity, suggest that true concordance of a particular neural tube anomaly occurs only in monozygotic (MZ) twins. It also seems that even ASB concordance occurs in DZ twins only at a rate comparable with recurrence in siblings. This confirms the earlier refutation (Field and Kerr, 1974) of the supposition of Nance (1971) that MZ twin pairs are strikingly discordant for ASB compared with DZ pairs. However, the evidence seems to go further than Field's assertion that MZ and DZ pairs are affected about equally. Concordance in DZ twins is in comparison with sibling data, but MZ pairs show a significantly higher rate of concordance in both categories. Finally, the incidence of ASB in Izmir compared with the areas of ethnic orgin of the Turks, and the high representation of families from Balkan areas where the incidence more closely resembles that of Izmir, suggest that the genetic factor is important in this area.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Epidemiology and Community Health
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
33
Sayı
3
