Development and Characterization of Voriconazole Loaded in Situ Gel Formulations for Ophthalmic Application
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of the this research was to prepare and evaluate the potential use of in situ gel formulations for ocular delivery of voriconazole for the treatment of fungal keratitis. An in situ gelling system was used to increase the residence time and thus the bioavailability of voriconazole in ocular mucosa. Temperature triggered in situ gel formulations were prepared by cold method using polymers like poloxamer 188, poloxamer 407 and sodium alginate. Finally, concentration of voriconazole in formulations was 0.1% (w/w). These formulations were evaluated for clarity, sol-gel transition temperature, gelling capacity, pH, viscosity and drug content. the gelation temperatures of all the formulations were within the range of 32-34°C. All the formulations exhibited fairly uniform drug content. Furthermore in vitro drug release and antifungal activity of these formulations were also evaluated. Drug release study of all the formulations showed sustained release properties. in conclusion, voriconazole loaded in situ gels could be offered as a promising strategy for ocular drug delivery for the treatment of fungal keratitis.
Oküler Uygulama için Vorikonazol Yüklü in Situ Jel Formülasyonlarının Geliştirilmesi ve Karakterizasyonu
Oküler Uygulama için Vorikonazol Yüklü in Situ Jel Formülasyonlarının Geliştirilmesi ve Karakterizasyonu
Açıklama
Anahtar Kelimeler
0-Belirlenecek
Kaynak
Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
3
