Lens Lipid peroxides and glutathione concentrations in diabetic cataract
Küçük Resim Yok
Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Soc Medicine Press Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aims to explore the role of reactive oxygen radicals in the genesis of diabetic cataract. Lipid peroxide (LPO) concentrations in senile (n = 30) and diabetic (n = 14) cataractous lenses, were determined as thiobarbituric acid-reactive substances (TEARS) by a method modified from Satoh and Yagi, and reduced glutathione (GSH) concentrations were measured according to Beutler. Lens LPO levels (mean, SD; nmol TBARS/g protein) were significantly higher in diabetics (107.54, 18.12) than senile cataractous subjects (53.54, 15.48) (P < 0.0001). Lens GSH levels (mean, SD; nmol/g protein) showed no significant difference between diabetics (4.29, 2.05) and senile cataractous subjects (4.68, 3.12). These results suggest that free radical damage is more effective in the genesis of diabetic cataract than in senile cataract.
Açıklama
Anahtar Kelimeler
free radicals, oxidative stress, thiobarbituric acid-reactive substances, senile cataract
Kaynak
Annals of Clinical Biochemistry
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
34
