Metal Binding Antimicrobial Peptides in Nanoparticle Bio-functionalization: New Heights in Drug Delivery and Therapy
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Peptides are considered very important due to the diversity expressed through their amino acid sequence, structure variation, large spectrum, and their essential role in biological systems. Antimicrobial peptides (AMPs) emerged as a potent tool in therapy owing to their antimicrobial properties but also their ability to trespass the membranes, specificity, and low toxicity. They comprise a variety of peptides from which specific amino acid-rich peptides are of interest to the current review due to their features in metal interaction and cell penetration. Histidine-rich peptides such as Histatins belong to the metal binding salivary residing peptides with efficient antibacterial, antifungal, and wound-healing activities. Furthermore, their ability to activate in acidic environment attracted the attention to their potential in therapy. The current review covers the current knowledge about AMPs and critically assess the potential of associating with metal ions both structurally and functionally. This review provides interesting hints for the advantages provided by AMPs and metal ions in biomedicine, making use of their direct properties in brain diseases therapy or in the creation of new bio-functionalized nanoparticles for cancer diagnosis and treatment. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Açıklama
Anahtar Kelimeler
Antimicrobial peptides, Bio-functionalized nanoparticles, Brain diseases, Histatins, Histidine-rich peptides, Metal ions, bio functionalized nanoparticle, camptothecin, carbon nanotube, cell penetrating peptide, dendrimer, histatin, histatin 1, histatin 10, histatin 11, histatin 12, histatin 2, histatin 3, histatin 4, histatin 5, histatin 6, histatin 7, histatin 8, histatin 9, histidine, liposome, metal ion, nanoparticle, paclitaxel, podophyllotoxin, polymer, polypeptide antibiotic agent, proline rich protein, quantum dot, tyrosine, unclassified drug, unindexed drug, antiinfective agent, cation, nanoparticle, pore forming cytotoxic protein, Alzheimer disease, antineoplastic activity, cancer cell, cancer chemotherapy, cancer diagnosis, cancer therapy, classification, drug delivery system, human, malignant neoplasm, metal binding, micelle, microemulsion, nanotechnology, nonhuman, protein binding, protein function, protein structure, Review, traumatic brain injury, amino acid sequence, brain disease, chemistry, Amino Acid Sequence, Anti-Infective Agents, Brain Diseases, Cations, Drug Delivery Systems, Humans, Nanoparticles, Pore Forming Cytotoxic Proteins
Kaynak
Probiotics and Antimicrobial Proteins
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
12
Sayı
1
