The Role of Fc? Receptor Gene Polymorphism in Pediatric Renal Transplant Rejections
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the study reported herein was to determine whether panel-reactive antibody (PRA) and Fc?R gene polymorphism act in the same way on acute rejection (AR) and chronic rejection (CR) in children who have undergone renal transplantation. The study evaluated 56 children who underwent transplantation and 115 healthy subjects. AR was observed in 13 cases; CR was observed in 7 patients. The assessment for Fc?R of the groups in which AR was present showed statistical significance only for the Fc?IIA genotype. There was no statistical significance for either the Fc?IIIA or Fc?IIIB genotypes. Assessment of the Fc?IIA, IIIA, and IIIB genotypes of the groups in whom CR was present did not show statistical significance. As a result, the prediction of graft survival among transplant recipients is possible using molecular biology. The results of our study showed that individuals of the Fc?RIIA genotype seemed to have a poorer prognosis similar to some autoimmune diseases. These individuals constitute a risk group for AR. If other studies are conducted with more patients to demonstrate the relationship of other Fc?Rs to rejection, the resultant predictive knowledge about the value of genotypes may lead to improved outcomes following renal transplantation. © 2008 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Kaynak
Transplantation Proceedings
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
40
Sayı
10
