Photopolymerized poly(Ethylene glycol) diacrylate hydrogels for controlled release of ketoprofen
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, poly(ethylene glycol-diacrylate) (PEG-DA) hydrogels with two different concentrations, 30% and 50% w/w, were prepared by free radical polymerization method. Ethylene glycol dimethacrylate (EGDMA) and 2,2-dimethoxy-2-phenyl-acetophenone (DMPA) were used as cross-linking agent and photoinitiator, respectively. the model drug ketoprofen (KP) was incorporated into the hydrogel during photopolymerization and its release kinetics was tested spectrophotometrically at 256 nm in different buffer solutions of pH 7.5, 4.5, and 1.2. the results showed that the release of KP strongly depends on the dissolution of drug, initial polymer concentration, and the pH of the release medium. All of the obtained results were evaluated kinetically by first order and zero order, Higuchi and Hixon-Crowell kinetic models. the release mechanism was found to obey Higuchi and first order kinetics when the release data of the formulations were applied to the models in the different pH mediums.
Açıklama
Anahtar Kelimeler
Biyoloji
Kaynak
Hacettepe Journal of Biology and Chemistry
WoS Q Değeri
Scopus Q Değeri
Cilt
37
Sayı
4
