Conducting osteochondral injury model in rabbit knee: Pearls and pitfalls
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Osteochondral damage is a commonly encountered issue in the daily orthopedic practice and has been extensively researched across various areas, including tissue transplantations, tissue engi-neering products, stem cell applications, and cell culture studies. The absence of a universally accepted treatment as the gold standard for osteochondral damage indicates the necessity for fur-ther studies in this field in the future. Although the biomechanical characteristics of the rabbit knee do not perfectly mimic those of the human knee, experimental studies conducted on rabbit knees are considered the most practical experimental model for testing a well-constructed ex-perimental hypothesis. Our article endeavors to impart our practical insights and experiences to researchers without experience whom seeking to design studies utilizing this model. We aim to offer valuable guidance for preoperative, operative, and postoperative considerations. & BULL; Rabbits used in osteochondral healing models should be at least 4 months old or older. In-ducing damage in the trochlea is a well-established technique and relatively easy to apply. & BULL; Do not use pointy ended drills as it might create uneven damage. Do not place applied treat-ment agent in inappropriate level in relation to the surrounding cartilage surface.
Açıklama
Anahtar Kelimeler
Rodent, Animal experiment, Scaffold, Chondral damage, Defects, Repair, Weight, Growth
Kaynak
Methodsx
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
11
