Effects of estrogen-only therapy on LDL oxidation in women with hysterectomy: Does paraoxonase genotype play a role?
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: This study investigated the effects of estrogen-only therapy on lipid profile (through susceptibility of low density lipoproteins to oxidation) and on oxidant-antioxidant parameters in surgical menopausal women. PON genotypes are also evaluated considering that they may be associated with the personal differences observed in antioxidant effects induced by estrogen. Methods: Thirty women who had undergone hysterectomy + bilateral ovariectomy in the last 3 years. with causes other than malignancy were included and given estrogen-only (Premarin-Wyeth Inc. 0.625 mg/day/6 months, equine conjugated estrogen). Blood samples were collected at baseline, first and sixth month of treatment. Serum (total antioxidant activity-TAO and PON activity), erythrocyte (TBARS and catalase activity), LDL and Cu2+ induced ox-LDL (TBARS and diene levels) samples were evaluated and PON1 192 polymorphisms were determined by PCR amplification & restriction enzyme digestion. Results: At the sixth month, a higher TAO activity (p = 0.016) and a lower eTBARS (p = 0.028) were detected compared to the basal values. LDL and Cu induced alpha-LDL TBARS levels at the sixth month of treatment were significantly (p = 0.012 and 0.026, respectively) lower compared to the pretreatment values. Baseline eTBARS (p = 0.007) LDL TBARS (p = 0.044) and eCAT (p = 0.033) activities were significantly higher in homozygote Q allele carriers compared to subjects with R allele, LDL TBARS and Cu2+, induced ox-LDLTBARS of QQ subjects (p = 0.018 and 0.050) as well as LDL TBARS of QR subjects (p = 0.044) showed a significant decrease with estrogen-only treatment. Conclusions: Our study drives the attention to PON polymorphism in postmenopausal women who have risk for atherosclerosis. Although our data is limited, this study is the first that focuses on the role of PON genotypes in anti atherosclerotic effects of estrogen-only and provides important points for further studies. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
atherosclerosis, estrogen, hormone replacement therapy, surgical menopause, LDL oxidation, antioxidant, PON activity, PON genotype
Kaynak
Maturitas
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
53
Sayı
3
