Telomerase inhibition in breast cancer and breast cancer stem cells: a brief review
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Humana Press Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Breast cancer is a major health problem, accounting for one third of all cancers in women. There is no definitive treatment for breast cancer and its incidence is increasing worldwide every year. Furthermore, breast cancer stem cells cause resistance to radiation and chemotherapy. Telomerase is an enzyme that protects telomeres and is activated in 90% of cancer cells, and telomerase activation is a hallmark of cancer. In this review, we examine telomerase activation in breast cancer and breast cancer stem cells and the therapeutic effects of telomerase inhibition in these cells. In this review, we aim to highlight the importance and impact of telomerase inhibition in the treatment of breast cancer and the lack of studies specifically in breast cancer stem cells.
Açıklama
Anahtar Kelimeler
Breast cancer, Breast cancer stem cells (BCSCs), Inhibition, Telomerase
Kaynak
Medical Oncology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
42
Sayı
1
Künye
Yildirim, I., & Avci, C. B. (2024). Telomerase inhibition in breast cancer and breast cancer stem cells: A brief review. Medical Oncology (Northwood, London, England), 42(1), 14.
