Extracellular Vesicles as Natural Nanosized Delivery Systems for Small-Molecule Drugs and Genetic Material: Steps towards the Future Nanomedicines
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Canadian Soc Pharmaceutical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A new platform for drug, gene and peptide-protein delivery is emerging, under the common name of "extracellular vesicles". Extracellular vesicles (EVs) are 30-1000 nm-sized cell-derived, liposome-like vesicles. Current research on EVs as nano-delivery systems for small-molecule drugs and genetic material, reveal that these tiny, biologically-derived vesicles carry a great potential to boost the efficacy of many therapeutic protocols. Several features of EVs; from efficacy to safety, from passive to active targeting ability, the opportunity to be biologically or chemically labelled, and most importantly, their eobiotic origin make them promising candidate for development of the next generation personalized nanomedicines. The aim of this article is to provide a view on the current research in which EVs are used as drug/genetic material delivery systems. Their application areas, drug loading and targeting strategies, and biodistribution properties are discussed.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Pharmacy and Pharmaceutical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
18
Sayı
3
