Epigenetic signatures in gastric cancer: current knowledge and future perspectives
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis As
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
IntroductionGastric cancer (GC) is the fifth most common malignancy in the world and accounts for 7.7% of all cancer-related deaths. Early diagnosis of GC is critical in terms of prognosis, and aberrations at the molecular level, especially epigenetic alterations, manifest much earlier than histological findings. In recent years, there has been a great deal of research on the epigenomic profile of GC, and epigenetic alterations seem to play a more important role than genetic factors. With the introduction of epigenetic drugs into clinical use in the last decade, the importance of the epigenetic background of GC has increased considerably.Areas CoveredIn this review, we summarize the role of methylation changes, histone modifications, and non-coding RNAs in the pathogenesis of GC and how these signatures can be used as diagnostic and therapeutic targets in clinical management.Expert OpinionEpigenetic alterations take place before most genetic aberrations observed in GC and may have an initiating role in the pathogenesis of GC. They can be used as biomarkers in risk calculation, early diagnosis, and evaluation of prognosis of GC, as well as treatment targets.
Açıklama
Anahtar Kelimeler
Epigenetics, gastric cancer, histone modifications, methylation, noncoding RNA, Dna Methylation, Cell-Proliferation, Poor-Prognosis, Phase-I, Apoptosis, Inhibitor, Expression, Invasion, Gene, Classification
Kaynak
Expert Review of Molecular Diagnostics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
