Karaciğer kist hidatiği tedavisinde albendazol kullanan hastalarda kardeş kromatid değişimi (KKD) çalışması
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmaya karaciğer kist hidatik şikayetiyle Atatürk Eğitim ve Araştırma Hastanesi Mikrobiyoloji ve Genel Cerrahi Anabilim Dalı'na başvuran 13 kadın, 8 erkek toplam 21 hasta alınmıştır. Kist hidatikli hastalara operasyon öncesi ve sonrası albendazol verilmiştir. Bu çalışmanın amacı albendazolün muhtemel genotoksik etkilerini araştırmaktır. Kardeş Kromatid Değişimi (SCE), tedaviden sonra hastalardan alınan kan örneklerine uygulanmış ve kontrol grubuyla karşılaştırılarak albendazolün mutajenik etkisi araştırılmıştır. İstatistiksel analizler için Student-t testi kullanılmıştır.
A total of 21 patients including 13 females and 8 males who presented at the Microbiology and General Surgery Departments of the Atatürk Research and Training Hospital with complaints of liver cystic hydatid disease have been included in this study. Albendazole was administered to these cystic hydatid patients before and after surgery. the aim of this study was to investigate the probable genotoxic effects of albendazole. SCE testing was applied to the blood samples taken from patients after the treatment and the mutagenic effect of albendazole was investigated by comparison with the control group. Student t- test was used for the statistical analysis of the results.
A total of 21 patients including 13 females and 8 males who presented at the Microbiology and General Surgery Departments of the Atatürk Research and Training Hospital with complaints of liver cystic hydatid disease have been included in this study. Albendazole was administered to these cystic hydatid patients before and after surgery. the aim of this study was to investigate the probable genotoxic effects of albendazole. SCE testing was applied to the blood samples taken from patients after the treatment and the mutagenic effect of albendazole was investigated by comparison with the control group. Student t- test was used for the statistical analysis of the results.
Açıklama
Anahtar Kelimeler
Parazitoloji, Genel ve Dahili Tıp
Kaynak
Türkiye Parazitoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
29
Sayı
4
