Tüberküloz meninjit tanısında klinik ve laboratuvar bulgularının değerlendirilmesi
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tüberküloz meninjit tanısı ile sağaltıma alınmış olguların başvuru sırasındaki klinik özellikleri, beyin-omurilik sıvısı (BOS) biyokimyasal bulguları ile mikobakteriyolojik sonuçların karşılaştırılması amaçlanmıştır. Yirmiüç olgunun tümünde en az üç haftadan beri süren başağrısı, beş (%21) olguda diplopi ve strabismus, dört (%17) olguda fasiyal paralizi ve pitozis saptandı. Oniki (%52) olguda ise kişilik değişikliği düzeyinde bilinç değişikliği kaydedildi. Başlangıçtaki BOS bulgularında; olguların tümünde şekerin düşük, protein değerinin 100 mg/dl'nin üstünde ve mononükleer lökosit (MNL)'lerin egemen olduğu saptandı. Mycoıbacteriumtuberculosis yedi olguda (%30) mikroskopik bakı ile gösterildi, on (%43) olguda kültürden izole edildi. Dokuz olgunun yedisinde BOS'ta Transcription Mediated Amplification (TMA) testi olumlu bulundu. Altı olguda TMA olumluluğu kültür ve/veya mikroskopik olumluluk ile birlikte gürüldü. TMA testinin tüberküloz meninjitli olguların erken tanısında yararlı olduğu sonucuna varıldı.
The aim of this study was to compare the clinical signs, biochemical and mycobacteriologic findings at the beginning of hospitalisation in the patients diagnosed and started therapy as tuberculous meningitis. All of the twenty-three patients had headache lasting at least three weeks. In five (%21) diplopia and strabismus and in four (%17) facial paralysis and pitosis were observed. In twelve (%52) patients there was personality change. In the examination of all cerebrospinal fluid (CSF), the level of glucose was low, protein was higher than 100 mg/dl. In all of the CSF samples the mononucleer leucocyte dominancy was seen. Mycobacterium tuberculosis were seen in seven (%30) patients by microscopic examination and in ten (%43) by culture method. In seven out of nine Transcription Mediated Amplification (TMA) test in CSF were positive. In six patients TMA positivity were associated with culture and/or microscopic examination positivity. As a result, TMA test was found useful in the early diagnosis of tuberculous meningitis.
The aim of this study was to compare the clinical signs, biochemical and mycobacteriologic findings at the beginning of hospitalisation in the patients diagnosed and started therapy as tuberculous meningitis. All of the twenty-three patients had headache lasting at least three weeks. In five (%21) diplopia and strabismus and in four (%17) facial paralysis and pitosis were observed. In twelve (%52) patients there was personality change. In the examination of all cerebrospinal fluid (CSF), the level of glucose was low, protein was higher than 100 mg/dl. In all of the CSF samples the mononucleer leucocyte dominancy was seen. Mycobacterium tuberculosis were seen in seven (%30) patients by microscopic examination and in ten (%43) by culture method. In seven out of nine Transcription Mediated Amplification (TMA) test in CSF were positive. In six patients TMA positivity were associated with culture and/or microscopic examination positivity. As a result, TMA test was found useful in the early diagnosis of tuberculous meningitis.
Açıklama
Anahtar Kelimeler
Enfeksiyon Hastalıkları
Kaynak
İnfeksiyon Dergisi
WoS Q Değeri
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Cilt
14
Sayı
3
