Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. the structures of the newly synthesized compounds 11-15 were evaluated by 1 H NMR, IR, MS-APCI and elemental analysis. Compounds (1-15) were tested against standard strains of Gram(+), Gram(?) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis. It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electron- donating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2- phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin.
Açıklama
Anahtar Kelimeler
0-Belirlenecek
Kaynak
Marmara Pharmaceutical Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
2
