Scintigraphic imaging with Tc-99m exorphin C in rabbits
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Exorphin C is a peptide with five amino acids [(Tyr-Pro-Ile-Ser-Leu) Trifluoroacetate salt] (Sigma) that has an affinity to opioid receptor-expressing tissues and tumors. Exorphin-C was labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Then, we investigated its radiopharmaccutical potential as opioid receptor-expressing tissue on rabbits. Quality controls were performed by ITLC, paper electrophoresis and HPLC. Labeling efficiency was higher than 98%. The compound was stable for at least 5 h at room temperature. Scintigraphic imaging with Tc-99m-GH-exorphin C (Tc-99m-GE) was performed on male Albino rabbits. Static images were obtained from anterior projection using a Camstar XR/T gamma camera at several time intervals. Although a significant amount of activity was seen in the brain, less activity was seen on receptor saturation studies at 30 min. Slight hepatobiliary excretion was seen, though the main excretion route was renal. After saturating, the receptor hepatobiliary excretion was not seen; the only excretion route was renal. (c) 2004 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
exophin C, Tc-99m-GE, Tc-99m-GH, Tc-99m-labeled peptides, rabbit, scintigraphy
Kaynak
Applied Radiation and Isotopes
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
62
Sayı
6
