Design of chemobrionic and biochemobrionic scaffolds for bone tissue engineering
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chemobrionic systems have attracted great attention in material science for development of novel biomimetic materials. This study aims to design a new bioactive material by integrating biosilica into chemobrionic structure, which will be called biochemobrionic, and to comparatively investigate the use of both chemobrionic and biochemobrionic materials as bone scaffolds. Biosilica, isolated from Amphora sp. diatom, was integrated into chemobrionic structure, and a comprehensive set of analysis was conducted to evaluate their morphological, chemical, mechanical, thermal, and biodegradation properties. Then, the effects of both scaffolds on cell biocompatibility and osteogenic differentiation capacity were assessed. Cells attached to the scaffolds, spread out, and covered the entire surface, indicating the absence of cytotoxicity. Biochemobrionic scaffold exhibited a higher level of mineralization and bone formation than the chemobrionic structure due to the osteogenic activity of biosilica. These results present a comprehensive and pioneering understanding of the potential of (bio)chemobrionics for bone regeneration. © The Author(s) 2024.
Açıklama
Anahtar Kelimeler
Animals, Biocompatible Materials, Bone and Bones, Bone Regeneration, Cell Differentiation, Diatoms, Humans, Osteogenesis, Tissue Engineering, Tissue Scaffolds, biomaterial, animal, bone, bone development, bone regeneration, cell differentiation, chemistry, diatom, drug effect, human, physiology, procedures, tissue engineering, tissue scaffold
Kaynak
Scientific Reports
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
14
Sayı
1
