The effect of long term nicotine exposure on nicotine addiction and fetal growth
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sıçanlarda koitusdan önce başlayıp gebelik boyunca ve lakasyon döneminde devam eden nikotin maruziyetinin doğum oranı, etal büyüme ve nikotin bağımlılığına olan etkilerinin araştırılması Gereç ve Yöntemler: On dişi Swiss Albino sıçan kontrol grubu (n=5) ve nikotin grubu (n=5) olarak iki gruba ayrıldı ve aralarına 2 erkek sıçan eklenerek gebe kalmaları sağlandı. Kontrol grubuna normal çme suyu verilirken, nikotin grubuna içme suyu içerisinde 0.4 mg/ kg vücut ağırlığı/gün nikotin eklendi. Doğumdan sonra yavru ratların vücut ağırlıkları, 6 hafta boyunca haftalık kaydedildi ve su tercihleri değerlendirildi. Bu arada nikotin grubunun yavru sıçanları 0.4 mg/kg/ gün nikotin 12 ay boyunca devam ederken, kontroller normal içme suyuna devam etti. Bulgular: Altı hafta sonunda nikotin grubundaki 43 sıçanın 30’u (%69) ve kontrol grubundaki 35 sıçanın 7’si (%20) nikotin eklenmiş suyu tercih etti (p<0.05). İki grup arasında doğumda ve 6 hafta boyunca kaydedilen vücut ağırlıkları arasında herhangi bir farklılık saptanmazken, 12 aylık nikotin maruziyeti sonunda nikotin grubunun vücut ağırlığı istatistiki olarak anlamlı düşük bulunmuştur (p<0.05). Sonuçlar: Nikotin, gebelik ve laktasyon dönemlerinde düşük dozda dahi kullanımı nikotin bağımlılığının gelişmesine etkili iken; doğum oranı ve yavru ratların doğumda ve 6 haftalık takibinde vücut ağırlıklaı üzerine bir etkisi izlenmemiştir. (J Turkish-German Gynecol Assoc 2012; 13: 237-41)
Objective: To investigate the effect of nicotine exposure starting be ore coitus and continuing during pregnancy and lactation period on delivery rate, fetal growth and nicotine addiction in rats. Material and Methods: Ten female Swiss Albino rats were divided nto 2 groups as the nicotine group (NG) (n=5), and the control group (n=5), conceived by adding 2 male rats to each group. While the control group was given only normal drinking water, 0.4 mg/kg body weight (BW)/day nicotine was given to the NG in drinking water. After delivery, the BWs of pups were recorded weekly for 6 weeks and their drinking water preferences were assessed. Meanwhile, pups of the NG continued to receive 0.4 mg/kg/day nicotine for 12 months while he controls continued with normal drinking water. Results: At the end of the 6th week, it was determined that 30 (69%) rats out of 43 in the NG and only 7 rats (20%) out of 35 in the control group preferred the nicotine added drinking water (p<0.05). No sig- nificant difference was observed between control and NGs in post natal birth weights and BWs recorded for 6 weeks. On the contrary, a significant decrease (p< 0.05) was observed in the BWs of NG at the end of 12 months nicotine exposure. Conclusion: Use of maternal nicotine in pregnancy and lactation pe riods, even at a low dose, may be effective in nicotine addiction de velopment although it may not affect delivery rate, and BWs of pups after delivery and during six weeks follow up in the lactation period. (J Turkish-German Gynecol Assoc 2012; 13: 237-41)
Objective: To investigate the effect of nicotine exposure starting be ore coitus and continuing during pregnancy and lactation period on delivery rate, fetal growth and nicotine addiction in rats. Material and Methods: Ten female Swiss Albino rats were divided nto 2 groups as the nicotine group (NG) (n=5), and the control group (n=5), conceived by adding 2 male rats to each group. While the control group was given only normal drinking water, 0.4 mg/kg body weight (BW)/day nicotine was given to the NG in drinking water. After delivery, the BWs of pups were recorded weekly for 6 weeks and their drinking water preferences were assessed. Meanwhile, pups of the NG continued to receive 0.4 mg/kg/day nicotine for 12 months while he controls continued with normal drinking water. Results: At the end of the 6th week, it was determined that 30 (69%) rats out of 43 in the NG and only 7 rats (20%) out of 35 in the control group preferred the nicotine added drinking water (p<0.05). No sig- nificant difference was observed between control and NGs in post natal birth weights and BWs recorded for 6 weeks. On the contrary, a significant decrease (p< 0.05) was observed in the BWs of NG at the end of 12 months nicotine exposure. Conclusion: Use of maternal nicotine in pregnancy and lactation pe riods, even at a low dose, may be effective in nicotine addiction de velopment although it may not affect delivery rate, and BWs of pups after delivery and during six weeks follow up in the lactation period. (J Turkish-German Gynecol Assoc 2012; 13: 237-41)
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
Journal of the Turkish-German Gynecological Association
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
4
