İdrar kültürlerinden soyutlanan bakteriler ve çeşitli antibiyotiklere in-vitro duyarlılıklarının değerlendirilmesi
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Toplum veya hastane kaynaklı üriner sistem infeksiyonları, yaygın antibiyotik kullanımına neden olan ve sık karşılaşılan infeksiyon hastalıklarıdır. Son yıllarda, hem hastane kaynaklı hem de toplum kaynaklı üriner infeksiyon etkenlerinde antimikrobiyallere karşı direnç artmaktadır. Bu çalışmada 2004 'te Ege Üniversitesi Tıp Fakültesi Bakteriyoloji Laboratuvarına gönderilen idrar kültürlerinden soyutlanan etkenlerin dağılımı ve bunların antibiyotik duyarlılıklarının retrospektif olarak incelenmesi amaçlanmıştır. İncelenen 24776 idrar örneğinden 4154 etken saptanmıştır (2129'u yatan hastalarda, 2025'i poliklinik hastalarında). Hastanede yatmakta olan hastalarda en sık soyutlanan bakteri Escherichia coli (% 52.4) olup bunu sırasıyla Klebsiella spp. (% 15.4), Pseudomonas aeruginosa (% 11.2), Enterococcus spp. (% 9.6), Enterobacter spp. (% 4.9), Acinetobacter spp. (% 3.4) ve Proteus spp. (%2.4) izlemiştir. Poliklinikten başvuran hastalarda da E.coli (% 71.5) en sık soyutlanan bakteridir, bunu Klebsiella spp. (% 15.5), Enterococcus spp. (% 3.5), Proteus spp. (% 3.3), P.aeruginosa (% 3) ve Enterobacter spp. (% 2.3) izlemiştir. E.coli kökenleri değerlendirildiğinde beta-laktamfbeta-laktamaz inhibitörleri kombinasyonları ile 2.-3. kuşak sefalosporinlere direnç oranları poliklinik hastalarında % 16-18, yatan hastalarda % 21-26.5 arasında olduğu görülmüştür. Aynı kökenlerde amikasine % 0.8-1.4, netilmisine % 2.8-4 direnç saptanmıştır. Yatan hastalardan soyutlanan E.coli kökenlerinin % 24.8'inde, poliklinik hastalarından soyutlanan E.coli kökenlerinin % 17.7'sinde genişlemiş spektrumlu beta-laktamaz saptanmıştır (p<0.001). Bir hastadan vankomisine dirençli Enterococcus spp. kökeni soyutlanmıştır.Yatan hastalardan izole edilen Pseudomonas ve Acinetobacter kökenlerindeki yüksek direnç oranları dikkat çekicidir. Üriner sistem infeksiy onlarında antimikrobiyal tedaviye genelde ampirik olarak başlanmaktadır. Bu nedenle her bölgenin ve hastanenin kendi duyarlılık sonuçlarını belirli aralıklarla izlemesi gereklidir.
Community acquired or nosocomial urinary tract infections are common infectious diseases, which cause widespread use of antibiotics. In recent years antimicrobial resistance is increasing in bacteria isolated from both nosocomial and community-acquired urinary tract infections. The aim of this study is to analyse the distribution and antimicrobial susceptibility of the causative agents isolated from urine cultures in Ege University Faculty of Medicine Bacteriology Laboratory in 2004. From 24776 urine samples, a total of 4154 bacterial growth (2129 from hospitalized patients, 2025 from outpatients) were obtained. The most frequently isolated bacteria from hospitalized patients was Escherichia coli (52.4 %), followed by Klebsiella spp. (15.4 %), Pseudomonas aeruginosa (11.2 %), Enterococcus spp. (9.6 %), Enterobacter spp. (4.9 %), Acinetobacter spp. (3.4 %) and Proteus spp. (2.4 %). The most frequently isolated bacteria from outpatients was E.coli (71.5 %), followed by Klebsiella spp. (15.5 %), Enterococcus spp. (3.5 %), Proteus spp. (3.3 %), P.aeruginosa (3 %) and Enterobacter spp. (2.3 %). When E. coli strains were evaluated, resistance rates to beta-lactamlbeta-lactamase combinations and 2nd and 3rd generation cephalosporins in outpatient clinic and hospitalized patients were 16-18 % and 21-26.5 %. Resistance rates to amikacin and netilmicin in the same isolates was 0.8-1.4 % and 2.8-4 %, respectively. Extended spectrum beta-lactamase rate in E.coli strains isolated from outpatient clinic patients and hospitalized patients were detected in 24.8 % and 17.7 % (p<0.001), respectively. A vancomycin resistant Enterococcus spp. strain was isolated from one patient. Resistance rates of Pseudomonas spp. and Acinetobacter spp. isolated from hospitalized patients are remarkable. In urinary tract infections antimicrobial therapy is usually started empirically. For this reason, each region and hospital should follow up their susceptibility results in certain time intervals.
Community acquired or nosocomial urinary tract infections are common infectious diseases, which cause widespread use of antibiotics. In recent years antimicrobial resistance is increasing in bacteria isolated from both nosocomial and community-acquired urinary tract infections. The aim of this study is to analyse the distribution and antimicrobial susceptibility of the causative agents isolated from urine cultures in Ege University Faculty of Medicine Bacteriology Laboratory in 2004. From 24776 urine samples, a total of 4154 bacterial growth (2129 from hospitalized patients, 2025 from outpatients) were obtained. The most frequently isolated bacteria from hospitalized patients was Escherichia coli (52.4 %), followed by Klebsiella spp. (15.4 %), Pseudomonas aeruginosa (11.2 %), Enterococcus spp. (9.6 %), Enterobacter spp. (4.9 %), Acinetobacter spp. (3.4 %) and Proteus spp. (2.4 %). The most frequently isolated bacteria from outpatients was E.coli (71.5 %), followed by Klebsiella spp. (15.5 %), Enterococcus spp. (3.5 %), Proteus spp. (3.3 %), P.aeruginosa (3 %) and Enterobacter spp. (2.3 %). When E. coli strains were evaluated, resistance rates to beta-lactamlbeta-lactamase combinations and 2nd and 3rd generation cephalosporins in outpatient clinic and hospitalized patients were 16-18 % and 21-26.5 %. Resistance rates to amikacin and netilmicin in the same isolates was 0.8-1.4 % and 2.8-4 %, respectively. Extended spectrum beta-lactamase rate in E.coli strains isolated from outpatient clinic patients and hospitalized patients were detected in 24.8 % and 17.7 % (p<0.001), respectively. A vancomycin resistant Enterococcus spp. strain was isolated from one patient. Resistance rates of Pseudomonas spp. and Acinetobacter spp. isolated from hospitalized patients are remarkable. In urinary tract infections antimicrobial therapy is usually started empirically. For this reason, each region and hospital should follow up their susceptibility results in certain time intervals.
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
ANKEM Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
20
Sayı
1
