Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi Ag
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical-chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by "in vivo" tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2-7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.
Açıklama
Anahtar Kelimeler
methotrexate, cryogel, acute toxicity, biocompatibility, release, pH responsiveness
Kaynak
Polymers
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
9
Sayı
4
