Mevsimsel allerjik rinit ve astımlı hastalardaki serum eozinofil katyonik protein (ECP) düzeyleri
Küçük Resim Yok
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Su çalışmada anamnez, deri testi've radyoallergosorbent test (RAST) sonuçlarına göre mevsimsel allerjik rinit ve astım tanısı konan 21 hasta ile 17 kişilik kontrol grubunda serum ECP düzeyleri araştırıldı. Aynı olgularda total IgE düzeyleri de bakılarak ECP düzeyleri ile korelasyonu incelendi. Hasta grubunun total IgE düzeyleri kontrol grubundan; rinit + astım tanısı alanların IgE düzeyleri de sadece rinit yakınması olan hastaların IgE düzeyinden daha yüksek saptandı (p<0.05). Hastaların ECP düzeyleri kontrol grubundan yüksek bulundu (p<0.05). Rinit + astımlı hastaların ECP düzeylerindeki artış sadece rinitli hastalarınkinden daha fazla olmasına karşın, fark istatistiksel olarak anlamlı değildi. Hastaların IgE düzeyleri ile ECP düzeyleri arasında pozitif korelasyon saptandı (r= 0.630, p<0.05). Serum ECP düzeylerinin, allerjik rinit ve allerjik astımda klinik aktivitenin bir göstergesi olduğu sonucuna varılmıştır.
The authors studied serum ECP levels both in 21 patients with seasonal allergic rhinitis and asthma diagnosed by history, skin tests, RAST and in 17 control subjects. Total IgE levels were also measured and correlated with ECP levels. Mean IgE level was found higher in patients than in controls (p<0.05). Patients with asthma and rhinitis had higher IgE values than those with rhinitis alone (p<0.05). ECP levels were found to be high in all patients when compared with controls (p<0.05). No statistically significant difference was found between ECP levels in patients with rhinitis + asthma and rhinitis group. Total IgE and ECP levels were correlated positively in the patients. The authors concluded that serum ECP level was a marker of clinical activity in patients with allergic rhinitis and allergic asthma.
The authors studied serum ECP levels both in 21 patients with seasonal allergic rhinitis and asthma diagnosed by history, skin tests, RAST and in 17 control subjects. Total IgE levels were also measured and correlated with ECP levels. Mean IgE level was found higher in patients than in controls (p<0.05). Patients with asthma and rhinitis had higher IgE values than those with rhinitis alone (p<0.05). ECP levels were found to be high in all patients when compared with controls (p<0.05). No statistically significant difference was found between ECP levels in patients with rhinitis + asthma and rhinitis group. Total IgE and ECP levels were correlated positively in the patients. The authors concluded that serum ECP level was a marker of clinical activity in patients with allergic rhinitis and allergic asthma.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Ege Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
3-4
