Vitiligo hastalarının birinci derece akrabalarında vitiligo, otoimmun ve otoinflamatuvar hastalıkların yatkınlığının araştırılması
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Tarih
2016
Yazarlar
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Cilt Başlığı
Yayıncı
Ege Üniversitesi, Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Vitiligo sık görülen edinsel, kronik bir pigmentasyon hastalığıdır. Genel olarak asemptomatik, keskin sınırlı, beyaz renkli yama veya maküler lezyonlarla karakterizedir. Etiyolojisi tam olarak açıklanamamıştır ancak son dönemlerdeki klinik çalışmalar melanositlerin sistemik destrüksiyonunu düşündürmektedir. Amaç: Bu çalışmadaki ana amaç Türk kökenli vitiligo hastaların birinci derece akrabalarında vitiligo, otoimmun ve otoinflamatuvar hastalıkların insidansının sağlıklı popülasyon ile kıyaslanmsıdır. Materyal ve Metod: Bu çalışmada Ege Üniversitesi Tıp fakültesi Deri ve Zührevi Hastalıkları AD polikliniğine başvuran Türk kökenli 71 vitiligolu hasta ve aynı sayıdaki vitiligo, otoimmun ve otoinflamatuvar hastalığı olmayan sağlıklı kontrol grubu ele alınmıştır. 20-50 yaş aralığındaki hasta ve kontrol grubunun anamnezleri alınarak dermatolojik muayeneleri yapıldı ve olgu rapor formları dolduruldu. Birinci derece akrabalar ile ilgili anamnezler de alınarak yine ilgili olgu rapor formları dolduruldu ve aile ağaçları çizildi. Bulgular: Vitiligo hastalığının insidansı hastaların birinci derece akrabalarında, kontrol sağlıklı gruba kıyasla yüksek olarak saptandı. Esasında vitiligosu olan hasta grubunun birinci derece akrabalarının %12.7'sinde vitiligo saptanırken, kontrol grubun birinci derece akrabalarında hiç vitiligo saptanmadı (ki-kare=9.609, p=0.003*). Hasta grubunun birinci derece akrabalarının %23.9'unda, kontrol grubunun birinci derece akrabalarının % 14.1'inde otoimmun hastalık saptanmıştır (ki-kare=1.214, p=0.271). Yine hasta grubunun birinci derece akrabalarının %2.8'inde, kontrol grubunun birinci derece akrabalarının %4.2'sinde otoinflamatuvar hastalık saptanmıştır. Böylece 2 grup arasında otoimrnun ve otoinflamatuvar hastalık açısından istatistiksel olarak anlamlı bir fark saptanmamıştır. Sonuç: Vitiligo hastalığı olan grubun birinci derece akrabalarında vitiligo, kontrol gruba kıyasla daha yüksek olarak saptanmış ve istatistiksel olarak anlamlı fark elde edilmiştir. Otoimmun hastalıklar daha yüksek oranda gözlenmiştir ancak istatistiksel olarak iki grup arasında anlamlı fark saptanmamıştır. Daha fazla hasta sayıları ve çok merkezli çalışmalar ile elde edilecek sonuçlara ihtiyaç vardır.
Introduction: Vitiligo is a common, acquired, chronic, pigmentary disorder. Clinically it is characterized by depigmented, white macules and patches with distinct borders. Although the exact ethiology is unknown, the recent studies point out to the systemic destruction of melanocytes. Objective: The main purpose of this study is to compare the incidence of vitiligo and other autoimmune and autoinflammatory diseases in the first degree relatives of Turkish patients with vitiligo and healthy control group. Matherials and Methods: In this study we assessed 71 Turkish patients with vitiligo and the same number of healthy control group (without any autoimmune/ autoinflammatory disease) between the age of 20-50 who admitted to outpatient clinic of dermatology at the hospital of Ege University. The anamnesis and the physical axaminations of the patients and the control group were completed and the patients’ files were prepared accordingly. The anamnesis about the first degree relatives of the patients with vitiligo were also asked and the family trees were drawn. Results: Incidence of vitiligo in first degree relatives of the patients was higher with 12.7% compared to the control group. Actually there was no vitiligo in first degree relatives of the control group. This result was highly significant statistically (odd ratio= 9.609 P= 0.003). The incidence of autoimmune disease in the first degree relatives of patients and control group were detected as 23.9 % and 14.1% respectively. Likewise the incidence of the autoinflammatory diseases were seen as 2.8% and 4.2% with the same order. Both of these results were not significant statistically. Conclusion : In this study, the incidence of vitiligo in the first degree relatives of the patients was found to be higher compared to the control group and it was highly significant statistically. The incidence of autoimmune diseases were also found to be higher in the first degree relatives of vitiligo patients compared with the control group, however this was not important statistically. Some future studies, especially multicenter ones with large patient groups will surely shed light on this issue.
Introduction: Vitiligo is a common, acquired, chronic, pigmentary disorder. Clinically it is characterized by depigmented, white macules and patches with distinct borders. Although the exact ethiology is unknown, the recent studies point out to the systemic destruction of melanocytes. Objective: The main purpose of this study is to compare the incidence of vitiligo and other autoimmune and autoinflammatory diseases in the first degree relatives of Turkish patients with vitiligo and healthy control group. Matherials and Methods: In this study we assessed 71 Turkish patients with vitiligo and the same number of healthy control group (without any autoimmune/ autoinflammatory disease) between the age of 20-50 who admitted to outpatient clinic of dermatology at the hospital of Ege University. The anamnesis and the physical axaminations of the patients and the control group were completed and the patients’ files were prepared accordingly. The anamnesis about the first degree relatives of the patients with vitiligo were also asked and the family trees were drawn. Results: Incidence of vitiligo in first degree relatives of the patients was higher with 12.7% compared to the control group. Actually there was no vitiligo in first degree relatives of the control group. This result was highly significant statistically (odd ratio= 9.609 P= 0.003). The incidence of autoimmune disease in the first degree relatives of patients and control group were detected as 23.9 % and 14.1% respectively. Likewise the incidence of the autoinflammatory diseases were seen as 2.8% and 4.2% with the same order. Both of these results were not significant statistically. Conclusion : In this study, the incidence of vitiligo in the first degree relatives of the patients was found to be higher compared to the control group and it was highly significant statistically. The incidence of autoimmune diseases were also found to be higher in the first degree relatives of vitiligo patients compared with the control group, however this was not important statistically. Some future studies, especially multicenter ones with large patient groups will surely shed light on this issue.
Açıklama
Anahtar Kelimeler
Vitiligo, Otoimmun, Otoinflamatuvar, Vitiligo, Autoimmunity, Autoinflammatory
