Gebelerde ilaç kullanımı: Son bir yıllık deneyim
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AMAÇ: Bu çalışma Ege Üniversitesi Tıp Fakültesi Farmakoloji ve Klinik Farmakoloji Anabilim Dalı’na gebeliği sırasında ilaç kullanılması nedeniyle sevk edilen hastaların geriye dönük olarak değerlendirilmesini amaçlamıştır. GEREÇ-YÖNTEM: Bu çalışmada 1 Ocak 2005- 31 Aralık 2005 tarihleri arasında kliniğimize başvuran hastalar retrospektif olarak değerlendirilmiştir. Tüm hastalar öncelikle bir kadın hastalıkları ve doğum uzmanı tarafından görülmüş olup ilaçların gebeliğe etkileri için temel olarak Amerika Birleşik Devletleri’nin Gıda ve İlaç Dairesi ( FDA ) veritabanı kullanılmıştır. BULGULAR: Çalışmamızda 345 gebe değerlendirilmiştir. Olguların % 43’ü Ege Üniversitesi Tıp Fakültesi Hastanesi’nin, % 24’ü diğer kamu hastanelerinin kadın hastalıkları ve doğum kliniklerinden, % 33’ü ise özel muayenehanelerden sevk edilmişti. Gebelerin % 30’u 25-29 yaş grubu içerisindeydi. Gebelik sırasında en sık kullanılan ilaçlar % 26.6 antiinfektifler, % 18.3 opioid ve opioid olmayan analjezikler, % 8.4 antidepresanlar, % 8.2 antigribal ilaçlardı. FDA sınıflamasına göre A kategoride yer alan ilaçlar % 1.4, B kategoride yer alan ilaçlar % 42.9, C kategoride yer alan ilaçlar % 42.4, D kategoride yer alan ilaçlar % 6.7 ve X kategoride yer alan ilaçlar % 3.1 idi. Gebelerin % 83.6 sı bu ilaçları ilk trimestirda kullanmıştı. Gebelerin sadece % 10’u tek bir etken maddeye maruz kalmıştı. SONUÇ: Kadınlar gebelikleri sırasında FDA sınıflamasına göre teratojenite potansiyeli olan ilaçlara önemli oranda maruz kalabilirler. İlaç reçetelendirilmesi sırasında gebeliğin sorgulanması bu oranı azaltabilir.
AIM: The aim of this study was to provide retrospective information about the prescribed drugs among pregnant woman who referred to Ege University Department of Pharmacology and Clinical Pharmacology. MATERIAL-METHOD: A retrospective study was conducted among pregnant woman who referred to our department between January 1, 2005 and December 31, 2005. Initially, all women were evaluated by an obstetrician and and the effects of the drugs during pregnancy was determined according to the United States Food and Drug Administration (FDA) risk classification system database RESULTS: 345 pregnant women were evaluated during the study. 43 % of the women were referred from Ege University Medical Faculty Department of Obstetrics and Gynaecology and 24 % from public hospitals, whereas 33% were consigned from doctor offices. 30% of the women were between 25-29 years of age. The most commonly prescribed drugs were anti-infectives (26.6 %), opioid and non-opioid analgesics (18.3%), antidepressants (8.4%) and flu medications (8.2 %). According to the FDA classification 1.4% of the prescribed drugs were in category A, 42.9% were in category B, 42.4% were in category C, 6.7% were in category D and 3.1% were in category X. 83.6% of the pregnant women had medications during first trimester of their pregnancies. Only 10% of the women received a single drug. CONCLUSIONS: Our study reveals that during their pregnancies an important proportion of women encounter drugs which might have a teratogenic potential. This proportion. can be reduced by interrogation of the patient about pregnancy before prescribing drugs.
AIM: The aim of this study was to provide retrospective information about the prescribed drugs among pregnant woman who referred to Ege University Department of Pharmacology and Clinical Pharmacology. MATERIAL-METHOD: A retrospective study was conducted among pregnant woman who referred to our department between January 1, 2005 and December 31, 2005. Initially, all women were evaluated by an obstetrician and and the effects of the drugs during pregnancy was determined according to the United States Food and Drug Administration (FDA) risk classification system database RESULTS: 345 pregnant women were evaluated during the study. 43 % of the women were referred from Ege University Medical Faculty Department of Obstetrics and Gynaecology and 24 % from public hospitals, whereas 33% were consigned from doctor offices. 30% of the women were between 25-29 years of age. The most commonly prescribed drugs were anti-infectives (26.6 %), opioid and non-opioid analgesics (18.3%), antidepressants (8.4%) and flu medications (8.2 %). According to the FDA classification 1.4% of the prescribed drugs were in category A, 42.9% were in category B, 42.4% were in category C, 6.7% were in category D and 3.1% were in category X. 83.6% of the pregnant women had medications during first trimester of their pregnancies. Only 10% of the women received a single drug. CONCLUSIONS: Our study reveals that during their pregnancies an important proportion of women encounter drugs which might have a teratogenic potential. This proportion. can be reduced by interrogation of the patient about pregnancy before prescribing drugs.
Açıklama
Anahtar Kelimeler
Eğitim, Özel
Kaynak
Uzmanlık Sonrası Eğitim ve Güncel Gelişmeler Derg. (Yeni Adı: Türk Jinekoloji ve Obstetrik Derneği Dergisi)
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
4
