Interferon-? gene and interferon-? receptor-1 gene polymorphisms in children with tuberculosis from Turkey
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Macrophage activation by interferon-? (IFN-?) is important in host resistance to tuberculosis (TB). In this study, the relationships of the +874 T/A polymorphism in the first intron of the IFN-? gene and intronic (CA)n polymorphic microsatellite marker of the interferon-? receptor 1 (IFN-?R1) gene to TB susceptibility were investigated in children. Forty children with TB and 67 age-matched controls were included. There were no significant differences between the allele frequencies and genotype frequencies of patient and control groups for the polymorphism +874 T/A in the IFN-? gene. Differences that were not statistically significant were found between the group of children with TB and the control group for the allelic markers (170 and 180) in the IFN-?R1 gene. The incidence of the allele 170 was higher in patients (30.9%) than in controls (17.4%), whereas the allele 180 was found to be more common in controls (9% vs 1.2%). In conclusion, no significant association was observed between the 874 T/A polymorphism found in the first exon of the IFN-? gene and TB susceptibility in Turkish children. © 2009 Informa UK Ltd.
Açıklama
Anahtar Kelimeler
Kaynak
Scandinavian Journal of Infectious Diseases
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
42
Sayı
1
