The prevalence and prognostic importance of the androgen receptor in triple-negative breast cancer
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Zerbinis Publications
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Triple-negative breast cancer (TNBC) has a significantly more aggressive course, higher recurrence rate, and shorter survival time than the other breast cancer types. The disease has molecular heterogeneity, and in a subset of patients, androgen receptor (AR) expression is present. Our study aimed to demonstrate prevalence of the AR positivity and examine the potential prognostic impact on patient survival. Methods: The study included patients aged >18 years who had a history of triple-negative nonmetastatic breast cancer and were followed-up and treated at Ege University Medical Faculty Hospital between 2005 and 2017. In our study,staining extent was expressed as a percentage, with ?1% positivity in stained preparates evaluated as AR positive. Results: 36% prevalence rate of AR expression was found in the TNBC group, consistent with previous studies.In our study, although no statistically significant relationship was found between overall and disease-free survival and AR expression in the patients with early-stage TNBC, disease-free survival was significantly longer in the AR-positive group. No significant difference in the number of locally advanced patients was found between the AR-positive and AR-negative groups. Conclusion: Although AR expression was found to have no statistically significant relationship with clinicopathological parameters and survival in the patients with TNBC, a larger series of studies is needed to validate the results of the present study. Furthermore, with the inclusion of AR expression level meaurement in routine histopathological examination in the TNBC group, with an expression rate of 36%, future AR-targeted therapies may show promising effectiveness. © 2021 Zerbinis Publications. All rights reserved.
Açıklama
Anahtar Kelimeler
Androgen receptor, Breast cancer, Immunohistochemistry, Triple-negative, androgen receptor, adult, advanced breast cancer, aged, Article, breast cancer recurrence, cancer prognosis, cancer staging, controlled study, disease free survival, follow up, histopathology, human, human tissue, immunohistochemistry, major clinical study, metastasis, overall survival, prevalence, protein expression, triple negative breast cancer
Kaynak
Journal of B.U.ON.
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
26
Sayı
6
