Does preoperative neutrophil-lymphocyte ratio indicate postoperative morbidity after repair of tetralogy of Fallot?
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada Fallot tetralojisi tamiri sonrasında ameliyat öncesi nötrofil-lenfosit oranının ameliyat sonrası morbiditeye etkisi araştırıldı.Ça lış ma pla nı: Bu retrospektif çalışmaya, Ağustos 2011 - Ekim 2013 tarihleri arasında Fallot tetralojisi tamiri yapılan 51 hasta (30 erkek, 21 kadın; ortanca yaş 2 yıl; 1-3. çeyreklik 1.19-3.65 yıl) alındı. Çalışma popülasyonu iki gruba ayrıldı: morbidite gelişmeyen hastalardan oluşan grup 1 ve morbiditeli hastalardan oluşan grup 2.Bul gu lar: Çalışma popülasyonunda mortalite gözlenmedi. Gruplar arasında ameliyat öncesi nötrofil-lenfosit oranı ortanca değerinde anlamlı fark saptanmadı [grup 1'de 0.87 (0.68-1.29) ve grup 2'de 0.75 (0.44-1.10); p=0.094]. Vazoaktif inotrop skoru, entübasyon süresi ve mediastinal drenaj indeksi grup 2'de anlamlı düzeyde daha yüksekti (sırasıyla p=0.014, p=0.001 ve p=0.003). Ameliyat öncesi ve sonrası C-reaktif protein, ilgili nötrofil-lenfosit oranı ile pozitif korelasyon gösterirken (sırasıyla p<0.01, p<0.01), ameliyat öncesi nötrofil-lenfosit oranı ameliyat sonrası C-reaktif protein ile korele değildi (p=0.701).So nuç: Çalışma bulgularımız, Fallot tetralojisinin tam düzeltme ameliyatından sonra ameliyat öncesi nötrofil-lenfosit oranı ve morbidite arasında anlamlı bir ilişki olmamasına rağmen, ameliyat öncesi nötrofil-lenfosit oranının anlık enflamatuvar durumun iyi bir göstergesi olabileceğini göstermektedir.
Background: in this study, we aimed to investigate the impact of preoperative neutrophil-lymphocyte ratio on postoperative morbidity after repair of tetralogy of Fallot.Methods: in this retrospective study, 51 patients (30 males, 21 females; median age 2 years; 1-3. quartiles 1.19 to 3.65 years) who underwent tetralogy of Fallot repair between August 2011 and October 2013 were included. the study population was divided into two groups: group 1 including patients without morbidity and group 2 including patients with morbidity.Results: No mortality was observed in the study population. There was no significant difference in the median of preoperative neutrophil-lymphocyte ratio between the groups [0.87 (0.68-1.29) in group 1 vs. 0.75 (0.44-1.10) in group 2; p=0.094]. Vasoactive inotrope score, duration of intubation, and mediastinal drainage index were significantly higher in group 2 (p=0.014, p=0.001 and p=0.003, respectively). While preoperative and postoperative C-reactive protein were positively correlated with the corresponding neutrophil-lymphocyte ratio (p<0.01, p<0.01, respectively), preoperative neutrophil-lymphocyte ratio was not correlated with postoperative C-reactive protein (p=0.701).Conclusion: Our study results showed that preoperative neutrophillymphocyte ratio can be a good predictor of instantaneous inflammatory status, although there is no significant relationship between preoperative neutrophil-lymphocyte ratio and morbidity after complete repair of tetralogy of Fallot.
Background: in this study, we aimed to investigate the impact of preoperative neutrophil-lymphocyte ratio on postoperative morbidity after repair of tetralogy of Fallot.Methods: in this retrospective study, 51 patients (30 males, 21 females; median age 2 years; 1-3. quartiles 1.19 to 3.65 years) who underwent tetralogy of Fallot repair between August 2011 and October 2013 were included. the study population was divided into two groups: group 1 including patients without morbidity and group 2 including patients with morbidity.Results: No mortality was observed in the study population. There was no significant difference in the median of preoperative neutrophil-lymphocyte ratio between the groups [0.87 (0.68-1.29) in group 1 vs. 0.75 (0.44-1.10) in group 2; p=0.094]. Vasoactive inotrope score, duration of intubation, and mediastinal drainage index were significantly higher in group 2 (p=0.014, p=0.001 and p=0.003, respectively). While preoperative and postoperative C-reactive protein were positively correlated with the corresponding neutrophil-lymphocyte ratio (p<0.01, p<0.01, respectively), preoperative neutrophil-lymphocyte ratio was not correlated with postoperative C-reactive protein (p=0.701).Conclusion: Our study results showed that preoperative neutrophillymphocyte ratio can be a good predictor of instantaneous inflammatory status, although there is no significant relationship between preoperative neutrophil-lymphocyte ratio and morbidity after complete repair of tetralogy of Fallot.
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi, Cerrahi
Kaynak
Türk Göğüs Kalp Damar Cerrahisi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
2
