Role of angiotensin-converting enzyme gene polymorphisms in children with sepsis and septic shock
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sepsis is characterized by a systemic inflammatory response. Its development and outcome are associated with host defense, pathogenicity of the microorganism and genetic polymorphisms. Genetic polymorphisms of the immune system genes have been shown to have a close relationship with the clinical outcomes of sepsis. Angiotensin-converting enzyme (ACE) plays a major role in the host defense against invading pathogens. It is therefore likely that polymorphisms in the ACE gene may have an important effect on determining the development and the outcome of sepsis. Methods: Ninety-eight children diagnosed as having sepsis and 287 healthy children were included in the study. Insertion/deletion polymorphisms were analyzed using reverse-hybridization assay. Results: The carriers of I allele (D/I genotype and I/I genotype) were found to have an increased risk of developing sepsis compared to the controls. Conclusion: DD genotype may play a positive role against the development of sepsis in healthy children. © 2008 Japan Pediatric Society.
Açıklama
Anahtar Kelimeler
Angiotensin-converting enzyme, Children, Gene expression, Sepsis
Kaynak
Pediatrics International
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
50
Sayı
4
