Primary glioblastoma of the Medulla Spinalis: A Report of Three Cases and Review of the literature
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Primer spinal kökenli GBM (spinal GBM) çok yaygın bir patoloji değildir. Bu çalışma, nadir olarak görülen bu tümörün klinik sunumu, seyri, yönetimi ve sonuçlarını özetlerken, 3 olguluk bir spinal GBM serisini bildirmektedir. Bu spinal GBM’ye sahip 3 olguluk seride, olgulardan biri tumor cerrahisinden 10 ay sonra hidrosefali nedeniyle opere edilmiştir. Bir diğer olguda ise, cerrahi girişimi takiben serebral metastaz gözlenmiştir. Post-operatif süreçte, tumor cerrahi sonrası olgulardan 2’si radyoterapi ve diğer olgu da kombine radyoterapi ve steroid terapiyle birlikte kemoterapi almıştır. İlgili literatürün gözden geçirilmesi, rapor edilen primer spinal GBM’li olguların sayıca azlığı nedeniyle bu konunun daha yakından incelenmesinin gerekliliğini ortaya koymaktadır. Beyin kökenli GBM’ye kıyasla, omurilikte görülen GBM daha saldırgandır; gelişimi sırasında beyine doğru yayılabilir (metastaz) ve bu yayılma neticesinde hidrosefaliye yol açabilir.
Primary spinal glioblastoma multiforme (spinal GBM) is not a very common entity. This paper presents an outline of this rare neoplasm, its clinical presentation, course, management and outcome and reports a 3-case series of spinal GBM. In this 3-case series with spinal GBM, one of the patients was operated for hydrocephalous 10 months later following the tumor surgery and another patient had cerebral metastasis after the surgery. In the postoperative period, two of the cases received radiotherapy and one received combined radiotherapy and chemotherapy with steroid therapy together following the tumor surgery. The review of the pertinent literature has revealed that due to the scarcity of the reported cases of primary spinal GBMs, this issue requires a closer look. GBM behaves more aggressive in medulla spinalis than it behaves when it originates from cerebrum. It may disseminate to the cerebrum during its course and it may cause hydrocephalus due to this dissemination (metastasis).
Primary spinal glioblastoma multiforme (spinal GBM) is not a very common entity. This paper presents an outline of this rare neoplasm, its clinical presentation, course, management and outcome and reports a 3-case series of spinal GBM. In this 3-case series with spinal GBM, one of the patients was operated for hydrocephalous 10 months later following the tumor surgery and another patient had cerebral metastasis after the surgery. In the postoperative period, two of the cases received radiotherapy and one received combined radiotherapy and chemotherapy with steroid therapy together following the tumor surgery. The review of the pertinent literature has revealed that due to the scarcity of the reported cases of primary spinal GBMs, this issue requires a closer look. GBM behaves more aggressive in medulla spinalis than it behaves when it originates from cerebrum. It may disseminate to the cerebrum during its course and it may cause hydrocephalus due to this dissemination (metastasis).
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Turkish Neurosurgery
WoS Q Değeri
Scopus Q Değeri
Cilt
23
Sayı
6
