Hepatic involvement in epstein-barr virus and cytomegalovirus infections: Evaluation of 31 cases [Epstein-barr virus ve sitomegalovirus enfeksiyonlariında karaciğer tutulumu: 31 Olgunun değerlendirilmesi]

Objective: Epstein-Barr virus (EBV)and Cytomegalovirus (CMV) are the main causes of infectious mononucleosis (IM) and IM-like sendrom in humans. In this study it was aimed to evaluate the clinical characteristics and liver enzymes changes in cases with EBV and CMV infections accompanying hepatic involvement in our department. Material and Methods: The hospital records of immune competent cases with EBV and CMV infections accompanying hepatic involvement who were followed up in our department between 2008-2016 were evaluated in terms of demographic characteristics, underlying diseases, laboratory, clinical data and treatment results retrospectively. Results: There were a total of 31 patients (19 men, 12 female) aged 27,6±10,6 (24 patients with EBV, 7 with CMV). The most common clinical symptoms were fever (27 patients 87,1%), fatigue (18 patients 58,1%), sore throat (12 patients 38,7%),vomiting (10 patients 32,3%), and swelling in the neck (9 patients 29,9%). Palpable servical lymph nodes (8 patients 25,8%) and hepatosplenomegaly (7 patients 22,5%) were the most common physical findings. Liver enzyme values on the 1st day and an average of 10 days after (10,9±5,8) (Range 3-30 day), 30 patients’ liver enyzmes follow up values are screened. All patients were hospitalized for an average of 6,9 days (±3,1, min: 3-max:20) and discharged as healthy. The icteric hepatitis was seen in 6,5% (2 patients). Conclusion: We conclude that the EBV and CMV serologic markers should be monitored as well as other hepatitis virus markers in the evaluation of cases with increased liver enzymes. © 2017 by Türkiye Klinikleri.