Postoperative adjuvant radiotherapy in stage IB carcinomas of the uterine cervix
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W.B. Saunders Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Between January 1987 and December 1992, amongst the cases who were evaluated and operated upon as clinical Stage IB carcinoma of the uterine cervix, 96 patients were treated with postoperative radiotherapy and the results were reviewed retrospectively in June 1996. Thirteen cases had undergone total abdominal hysterectomy and bilateral salpingoopherectomy, 41 had modified radical hysterectomy and 42 had radical hysterectomy. Postoperative radiotherapy was applied to cases with poor prognostic factors such as lymph node metastasis, deep stromal invasion and bulky tumour, or to cases with inadequate operation. External pelvic irradiation of 50.4-54 Gy without midline shielding and 20 Gy intracavitary (2 x 10 Gy of vaginal surface dose) irradiation were applied. Five-year overall and disease-free survival rates were 82.9% and 77.4%, respectively. There was no difference in survival rates due to the type of operation (P = 0.920). Factors that significantly affected the 5-year disease-free survivals by univariate analysis were lymph node metastasis (positive: 54.7%, negative: 84.8%; P < 0.001), tumour volume (> 4 cm: 63.4%, < 4 cm: 83.5%, P = 0.004), surgical margins (positive: 62.1%, negative: 83.1%, P = 0.029), deep stromal invasion (positive: 71.1%, negative: 92.6%, P = 0.056) and histopathological type (P = 0.036). In multivariate analysis, lymph node metastasis was the only independent prognostic factor (P = 0.008). The complication rates of Grade II (7.4%) and Grade III (5.1%) indicates that postoperative radiotherapy was tolerated well by the patients. The efficiency of postoperative radiotherapy in clinically stage IB cervix carcinomas with inadequate surgery or with poor prognostic criteria was discussed and it was concluded that it might have a positive contribution to survival with an acceptable complication rate.
Açıklama
Anahtar Kelimeler
Carcinoma of the uterine cervix, Postoperative radiotherapy, Prognostic factors
Kaynak
Radiography
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
4
Sayı
1
