Saliva, Serum Levels of Interleukin-21,-33 and Prostaglandin E2 in Patients with Generalised Aggressive or Chronic Periodontitis
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Quintessence Publishing Co Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: This cross-sectional study aims to evaluate saliva, serum levels of interleukin-21 (IL-21), IL-33, and prosta glandin E2 (PGE2) in patients with generalised chronic periodontitis or aggressive periodontitis. Materials and Methods: Before initiation of any periodontal treatment, saliva and serum samples were collected and clinical periodontal measurements were recorded from 94 participants (25 aggressive periodontitis patients, 25 chronic periodontitis patients, 44 periodontally healthy individuals). IL-21, IL-33 and PGE2 levels in serum and saliva samples were determined by ELISA. Data were tested statistically using Kruskal-Wallis, Mann-Whitney U-, and Spearman-rho rank tests. Results: Saliva IL-33 levels were statistically significantly higher in the chronic than the aggressive group (p < 0.05). Serum IL-33, saliva and serum IL-21 and PGE2 levels were similar in the two periodontitis groups. Saliva IL-33 levels correlated with age in the chronic periodontitis group (p < 0.05). Statistically significant positive correlations were found between serum, saliva PGE2 levels and plaque index (p < 0.05). IL-33 and IL-21 levels in serum samples positively correlated in the periodontitis groups (p < 0.05). Conclusion: IL-21 and PGE2 analysis did not exhibit discriminating data between generalised chronic and aggressive periodontitis, but the present findings support the role of these cytokines in periodontitis. Statistically significantly higher saliva IL-33 levels in the chronic periodontitis group warrant further research.
Açıklama
Anahtar Kelimeler
interleukin-21, interleukin-33, periodontitis, prostaglandin E2, saliva, serum
Kaynak
Oral Health & Preventive Dentistry
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
15
Sayı
4
