Cholestatic hepatic injury due to ciprofloxacine [Siprofloksasinin sebep oldugu kolestatik karaciger hasari]

In this report, we present a case of hepatic injury with severe cholestasis thought to be a consequence of a quinolone derivative ciprofloxacine. Symptoms appeared on the 5th day of the drug use and reached the maximum at second week together with the biochemical abnormalities. The liver injury was thought to be due to ciprofloxacine as viral markers and auotoantibodies were negative, and as we could not demonstrate a specific cause pathologically in association with the return of all the biochemical parameters to normal in 3 month. This case merits to be presented from the point that there are only three cases of symptomatic liver injury due to ciprofloxacine in literature and that it demonstrates all the drugs could be hepatotoxic sometimes leading severe symptoms.