Clinical periodontal status and inflammatory cytokines in primary sjögren syndrome and rheumatoid arthritis
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The aim of the present study is to compare the clinical periodontal findings as well as gingival crevicular fluid (GCF) and plasma levels of tumor necrosis factor-alpha (TNF-?), interleukin-1beta (IL-1ß), interferon gamma (IFN-?) and caspase-1 in primary Sjögren syndrome (pSS) and rheumatoid arthritis (RA) subjects. Methods: In the present case control study plasma and GCF samples were collected, full-mouth recordings comprising plaque index (PI), bleeding on probing (BOP) and probing depth (PD) were performed in 44 subjects with pSS, 39 subjects with RA and 30 systemically healthy subjects. Plasma and GCF TNF-?, IL-1ß, IFN-gamma and caspase-1 levels were determined by enzyme-linked immunosorbent assay. Results: There were no differences in GCF and plasma levels of IFN-? and TNF-? in all the study groups (p > 0.05). GCF levels of IL-1ß were higher in pSS group than healthy group (p = 0.035). Caspase-1 GCF levels were significantly higher in pSS group than RA group (p = 0.032). Highest plasma IL-1ß levels were detected in pSS compared to RA and healthy groups (p < 0.001). Healthy group has higher caspase-1 plasma levels than pSS and RA groups (p < 0.001). Conclusions: The results of the present study reveal that the periodontal status of patients with pSS does not differ from systemically healthy subjects. Further studies involving longitudinal assessments on larger populations with standardized patient inclusion criteria are needed to confirm the findings. © 2018 American Academy of Periodontology.
Açıklama
Anahtar Kelimeler
Caspase-1, Gingival crevicular fluid, Gingivitis, Interleukin-1beta, Plasma, Primary sjögren syndrome, Tumor necrosis factor-alpha
Kaynak
Journal of Periodontology
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
89
Sayı
8
