Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: Effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
S. Karger AG
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, coronary perfusion pressure and force of contraction were investigated in isolated hearts removed from arthritic rats by using the Langendorff method. A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipoxygenase (5-LOX) products, leukotriene B4 (LTB4) and LTC4 in coronary effluents. In vivo treatment with the dual inhibitor of cyclooxygenase (COX) and LOX, CI-986 (2 and 10 mg/kg/day) on days 14-26 following adjuvant injection, prevented the coronary vasoconstriction and the increased production of LTB4 and LTC4. These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries.
Açıklama
Anahtar Kelimeler
Adjuvant-induced arthritis, Arachidonic acid, Cyclooxygenase, Isolated rat heart, Leukotrienes, Lipoxygenase
Kaynak
Pharmacology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
60
Sayı
1
