No relationship between lipoprotein-associated phospholipase A2, proinflammatory cytokines, and neopterin in Alzheimer's disease
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA(2)) is a reported risk factor for dementia. However, the relationship between Alzheimer's disease (AD) and Lp-PLA(2) is still debatable and, to the best of our knowledge, no study has evaluated the associations between levels of Lp-PLA(2), proinflammatory cytokines, and neopterin in AD. Methods: In total, 59 patients with AD and 38 non-demented individuals were included in the case-control study. Fasting serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), neopterin, and Lp-PLA(2) were determined using ELISA. The associations between AD and each of the variables were analyzed by logistic regression. Results: The median Lp-PLA(2) levels in AD and controls were similar (P = 0.29, not significant). Median serum neopterin and IL-6 levels were significantly higher in patients with AD than in controls (P = 0.0001 and P = 0.03, respectively). In regression analyses, median neopterin levels, a lower level of education, and female gender were significantly associated with AD when compared with controls (OR, 31.44, 95% CI 3.59-275.28, P=0.002; OR, 4.35, 95% CI 1.13-16.61, P = 0.032; OR, 7.25, 95% CI 1.88-28.00, P = 0.004, respectively). Conclusion: In contrast to previous evidence suggesting its role in dementia and AD, Lp-PLA(2) enzyme levels were higher in the controls, and no relationship between Lp-PLA(2) and either proinflammatory cytokines or neopterin was identified in AD. Elevated neopterin levels may be considered inflammatory markers of AD. (C) 2016 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Lipoprotein-associated phospholipase A(2), Proinflammatory cytokine, Neopterin, Alzheimer's disease
Kaynak
Experimental Gerontology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
77
