SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SCHIFF AND AZO-SCHIFF BASE LIGANDS
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Babes-Bolyai University
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Schiff and azo-Schiff base derivatives were synthesized, identified and evaluated for their antimicrobial and antifungal activities against gram-positive bacteria, gram-negative bacteria and fungi such as Escherichia coli, Pseudomonas aureginosa, Staphylococcus aureus, Bacillus cereus, Salmonella typhimurium, Saccharomyces cerevisiae and Candida albicans. Chiral amides (2a-e) were synthesised by using D-Phenylglycine, L-Phenylalanine, L-valine, L-isoleucine and L-methionine. Experimental studies include the use of chiral amide derivatives (2a-e) of the five amino acids to synthesize the Schiff and azo-Schiff base derivatives of amides (3a-e, 4a-c and 4e). The structures of the compounds were determined by spectroscopic analyses (FTIR,1H-NMR, 13 C-NMR) and elemental analysis. Among the tested compounds, compound 3b and 3d were found to show the most potent inhibitory action against Gram positive and Gram negative bacteria. © 2023 STUDIA UBB CHEMIA.
Açıklama
Anahtar Kelimeler
amide, amino acid, azo-Schiff base, biological activity, Schiff base
Kaynak
Studia Universitatis Babes-Bolyai Chemia
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
2023
Sayı
1
