Serum lipoprotein concentrations in normal and preeclamptic women
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Normal gebelikle karşılaştırıldığında preeklampside plasma trigliserid, total kolesterol, HDL-kolesterol, LDL-kolesterol, apolipoprotein A-l ve apolipoprotein B düzeylerinde anlamlı artış olduğunu saptamak Gereç ve Yöntem: Plasma trigliserid, total kolesterol, HDL-kolesterol, LDL-kolesterol, apolipoprotein A-l ve apolipoprotein B düzeyleri gebelik haftası ve yaşça eşleştirilmiş 10 sağlıklı gebe ve 10 preeklamptik olguda ölçülerek karşılaştırıldı. Bulgular: Kontrol olguları ile karşılaştırıldığında preeklamptik olgularda median plasma trigliserid düzeyi daha yüksek (339 ve 167.5, p>0.05); total kolesterol düzeyi daha yüksek (277 ve 227.5, p>0.05); HDL-kolesterol düzeyi daha düşük (58.5 ve 69, p>0.05) ve LDL-kolesterol düzeyi daha yüksek (146 ve 123, p>0.05) olarak saptandı. Sonuç: Preeklamptik olgularda dolaşımda yüksek plasma trigliserid, total kolesterol ve trigliseridden-zengin lipoproteinler bulundu. Bu yapılar endotelyal disfonksiyon ve preeklampsi oluşumuna katkıda bulunabilmektedir.
OBJECTIVE: To determine whether plasma levels of triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-l and apolipoprotein B are significantly increased in women with preeclampsia compared with concentrations seen in normal pregnancy. MATERIALS AND METHOD: Plasma concentrations of triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-l and apolipoprotein B were measured in 10 women with preeclampsia and in 10 healthy pregnant controls matched for age and gestational age. RESULTS: Women with preeclampsia exhibited higher median plasma triglyceride (339 versus 167.5, P>0.05), higher median plasma total cholesterol (277 versus 227.5, P>0.05), lower median plasma HDL-cholesterol (58.5 versus 69, P>0.05) and higher median plasma LDL-cholesterol (146 versus 123, P>0.05) compared with controls. CONCLUSION: Women with preeclampsia exhibit elevated concentrations of plasma triglyceride, total cholesterol and triglyceride-rich lipoproteins in the circulation. These particles are potential contributers to endothelial dysfunction and expression of preeclampsia.
OBJECTIVE: To determine whether plasma levels of triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-l and apolipoprotein B are significantly increased in women with preeclampsia compared with concentrations seen in normal pregnancy. MATERIALS AND METHOD: Plasma concentrations of triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-l and apolipoprotein B were measured in 10 women with preeclampsia and in 10 healthy pregnant controls matched for age and gestational age. RESULTS: Women with preeclampsia exhibited higher median plasma triglyceride (339 versus 167.5, P>0.05), higher median plasma total cholesterol (277 versus 227.5, P>0.05), lower median plasma HDL-cholesterol (58.5 versus 69, P>0.05) and higher median plasma LDL-cholesterol (146 versus 123, P>0.05) compared with controls. CONCLUSION: Women with preeclampsia exhibit elevated concentrations of plasma triglyceride, total cholesterol and triglyceride-rich lipoproteins in the circulation. These particles are potential contributers to endothelial dysfunction and expression of preeclampsia.
Açıklama
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
GORM:Gynecology Obstetrics & Reproductive Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
3
