Exploiting the extemporaneousness of radiopharmaceuticals: Radiolabeling stability under diverse conditions
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Radiopharmaceuticals are radioactive drugs, with a very short shelf life, in most of the cases. The number of proceedings using radiopharmaceuticals increases each day worldwide and for many countries the price of radiopharmaceuticals can represent a limitation in the offer of this drug for more patients. Nonetheless, the shortage of important radionuclides is a serious issue and may also affect the use and distribution of these drugs for more patients globally, especially in low and middle income countries. In this direction, the need to avoid waste of these drugs is crucial. In this study we have evaluated the stability of two radiopharmaceuticals (MDP and DTPA) under different conditions in order to propose the extension of shelf life. The results showed that is possible to have stable radiopharmaceuticals (both MDP and DTPA) even 24hs post labeling process when storage properly. The data may represent an advance in the field of Radiopharmacy, providing news perspectives for radiopharmaceuticals shelf life. © 2022 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Quality control, Radionuclide, Radiopharmacy, Stability, radiopharmaceutical agent, pentetic acid, radioisotope, radiopharmaceutical agent, Article, drug stability, human, middle income country, nuclear pharmacy, paper chromatography, radiochemistry, radiolabeling, shelf life, thin layer chromatography, Humans, Pentetic Acid, Radioisotopes, Radiopharmaceuticals
Kaynak
Journal of Pharmaceutical and Biomedical Analysis
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
221
