Severe intestinal graft versus host disease after donor lymphocyte infusion; response to extracorporeal photochemotherapy
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We present a patient with acute myelogenous leukemia who developed severe acute intestinal graft versus host disease (GVHD) after donor lymphocyte infusion (DLI) following non-myeloablative allogeneic peripheral blood stem cell transplantation (allo-PBCT). One month after DLI, patient developed severe abdominal cramps, watery diarrhea without any signs or symptoms of the skin and liver GVHD. Treatment with steroid, cyclosporine A, tacrolimus and mycophenolat mofetil were not effective in controlling intestinal symptoms. Extracorporeal photochemotherapy (ECP), a recently used procedure in the treatment of GVHD was employed periodically and the symptoms subsided gradually. Acute GVHD after DLI may occur severely and atypically, but being limited to the intestine has rarely been reported. © 2005 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
AML, Extracorporeal photochemotherapy, Intestinal GVHD
Kaynak
Transfusion and Apheresis Science
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
33
Sayı
2
