Ramsay Hunt Sendromunun Nadir Bir Komplikasyonu: Sinüs Ven Trombozu
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ramsay Hunt sendromu akut olarak gelişen fasiyal felç ve buna neden olan varisella zoster virüsü (VZV)’ne bağlı dış kulak kanalının ve kulak derisinin veziküler lezyon birlikteliğidir. Bell felci gibi %50 spontan iyileşme sıklığı olmasına rağmen Ramsay Hunt sendromu nun morbiditesi daha yüksek, komplikasyonları daha tehlikelidir. VZV birkaç 10 yıllık latans devrinden sonra, özellikle yaşlılarda ve im münyetmezliği olan kişilerde, genikulat gangliyonunda herpes zoster veya Ramsay Hunt sendromu şeklinde reaktivasyon gösterebilir. Nadir olarak, VZV büyük serebral arterlere yayılarak vaskülopati ya da vaskülite neden olarak strokla sonuçlanabilir. Kanser, immünyet mezlik sendromu gibi immünyetmezliği olan kişilerde virüs daha derin dokulara penetre olabilir. Ender olarak miyelit, küçük damar vaskülopatisi, sinüs ven trombozu, serebellit, ensefalit, ventrikülit, kalıcı işitme kaybı gibi komplikasyonlar gelişebilir. VZV için kan ve beyin omurilik sıvısında yapılan çalışmalar arasında en hızlı ve sensitif test polimeraz zincir reaksiyonudur. Biz serebral sinüs ven trom bozu ile komplike olan Ramsay Hunt sendromu olan bir olgu sunduk. Hastaya antikoagülasyon ve asiklovir tedavisi verildi. Erken te davi ile fasiyal sinir felci ve sinüs ven trombozu düzelebilir.
Ramsay Hunt syndrome is a rare affection characterized by peripheral facial paralysis, skin eruption in the auricular canal and cochleovestibular symptoms. It is produced by varicella zoster virus (VZV) reactivation in the geniculate ganglia. In elderly and immunocompromised individuals, the virus may reactivate to produce shingles (zoster). After zoster resolves, many elderly patients experience postherpetic neuralgia. Uncommonly, VZV can spread to large cerebral arteries to cause a spectrum of large-vessel vascular damage, ranging from vasculopathy to vasculitis, with stroke. In immunocompromised individuals, especially those with cancer or acquired immunodeficiency syndrome, deeper tissue penetration of the virus may occur (as compared with immunocompetent individuals), with resultant myelitis, small-vessel vasculopathy, ventriculitis, and meningoencephalitis. Polymerase chain reaction analysis of cerebrospinal fluid remains the mainstay for diagnosing the neurologic complications of VZV during over a patient’s lifetime. We report a case of Ramsay Hunt syndrome complicated with cerebral venous thrombosis. The patient received treatment with acyclovir and anticoagulation. Early treatment with acyclovir therapy and anticoagulation could improve the recovery rate of facial nerve palsy and sinus vein thrombosis.
Ramsay Hunt syndrome is a rare affection characterized by peripheral facial paralysis, skin eruption in the auricular canal and cochleovestibular symptoms. It is produced by varicella zoster virus (VZV) reactivation in the geniculate ganglia. In elderly and immunocompromised individuals, the virus may reactivate to produce shingles (zoster). After zoster resolves, many elderly patients experience postherpetic neuralgia. Uncommonly, VZV can spread to large cerebral arteries to cause a spectrum of large-vessel vascular damage, ranging from vasculopathy to vasculitis, with stroke. In immunocompromised individuals, especially those with cancer or acquired immunodeficiency syndrome, deeper tissue penetration of the virus may occur (as compared with immunocompetent individuals), with resultant myelitis, small-vessel vasculopathy, ventriculitis, and meningoencephalitis. Polymerase chain reaction analysis of cerebrospinal fluid remains the mainstay for diagnosing the neurologic complications of VZV during over a patient’s lifetime. We report a case of Ramsay Hunt syndrome complicated with cerebral venous thrombosis. The patient received treatment with acyclovir and anticoagulation. Early treatment with acyclovir therapy and anticoagulation could improve the recovery rate of facial nerve palsy and sinus vein thrombosis.
Açıklama
Anahtar Kelimeler
Nörolojik Bilimler
Kaynak
Türk Nöroloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
1
