Erythrocyte membrane ATPase activities in patients with chronic active hepatitis B and C virus infections
Küçük Resim Yok
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the present study was to obtain erythrocyte membrane fractions from patients with chronic active hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Na+,K+ ATPase activities were significantly lower (P < 0.005) in HBV related chronic active hepatitis (n = 20, 0.134 +/- 0.073 mu mol P/mg protein per h) and in HCV hepatitis (n = 11, 0.144 +/- 0.049 mu mol P/mg protein per h) when compared to control group (n = 10, 0.219 +/- 0.055 mu mol P/mg protein per h). Both types of chronic active hepatitis B and C have markedly altered erythrocyte membrane Na+,K+ ATPase activities that can be indicative of hepatic cell damage in humans. Although HBV and HCV infections are based on diverse mechanisms of action on their effect in liver injury, they cause similar effects on membrane ATPase activities. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
erythrocyte membrane, Na+,K+ ATPase, Mg2+ ATPase, Ca2+ ATPase, chronic active hepatitis B, chronic active hepatitis C, liver histopathology
Kaynak
Hepatology Research
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
13
Sayı
3