Erythrocyte membrane ATPase activities in patients with chronic active hepatitis B and C virus infections

Küçük Resim Yok

Tarih

1999

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Sci Ireland Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The aim of the present study was to obtain erythrocyte membrane fractions from patients with chronic active hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Na+,K+ ATPase activities were significantly lower (P < 0.005) in HBV related chronic active hepatitis (n = 20, 0.134 +/- 0.073 mu mol P/mg protein per h) and in HCV hepatitis (n = 11, 0.144 +/- 0.049 mu mol P/mg protein per h) when compared to control group (n = 10, 0.219 +/- 0.055 mu mol P/mg protein per h). Both types of chronic active hepatitis B and C have markedly altered erythrocyte membrane Na+,K+ ATPase activities that can be indicative of hepatic cell damage in humans. Although HBV and HCV infections are based on diverse mechanisms of action on their effect in liver injury, they cause similar effects on membrane ATPase activities. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Açıklama

Anahtar Kelimeler

erythrocyte membrane, Na+,K+ ATPase, Mg2+ ATPase, Ca2+ ATPase, chronic active hepatitis B, chronic active hepatitis C, liver histopathology

Kaynak

Hepatology Research

WoS Q Değeri

Q3

Scopus Q Değeri

N/A

Cilt

13

Sayı

3

Künye