Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cig Media Group, Lp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway associated malignancies after confirmation with clinical studies. (C) 2015 Elsevier Inc. All rights reserved.
Açıklama
Annual Meeting of the Society-of-Hematologic-Oncology -- SEP 17-20, 2014 -- Houston, TX
Anahtar Kelimeler
Apoptosis, Chronic myeloid leukemia, Dasatinib, JAK/STAT pathway, STAT5
Kaynak
Clinical Lymphoma Myeloma & Leukemia
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
15
