Cellulose based biopolymer nanoscaffold: A possible biomedical applications
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, a combination of cellulose nanofiber (CNF), coffee beans powder (CBP), and reduced graphene oxide (rGO) are used to design a nanowound dressing sheet (Nano-WDS), by vacuum pressure, for their sustained application in wound healing. Nano-WDS was analysed for its mechanical, antimicrobial, biocompatibility, etc., The Nano-WDS had favourable results of the tensile strength (12.85 ± 0.10 MPa), elongation at break (09.45 ± 0.28 %), water absorption (31.14 ± 0.04 %), and thickness (00.76 ± 0.02 mm). The biocompatibility study of Nano-WDS was analysed using human keratinocyte cell line (HaCaT), which showed excellent cell growth. The antibacterial activity was reflected in the Nano-WDS against the E.coli and S.aureus bacteria. Cellulose comprises the glucose unit and reduced graphene oxides are combined to create macromolecular interaction. The surface activity of cellulose-formed nanowound dressing sheet demonstrates a wound tissue engineering application. Based on the result of the study was proved suitable for bioactive wound dressing applications. The research proves that these Nano-WDS could be successfully used for the production of wound healing materials. © 2023 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Biomaterials, Nanocomposites, Thin films, Biocompatibility, Biopolymers, Cell culture, Cell proliferation, Cellulose films, Escherichia coli, Graphene, Medical applications, Nanocomposite films, Nanocomposites, Tensile strength, Tissue engineering, Water absorption, Biomedical applications, Cellulose nanofibers, Coffee beans, Elongation-at-break, Mechanical, Nanoscaffolds, Reduced graphene oxides, Thin-films, Vacuum pressure, Wound healing, Cellulose
Kaynak
International Journal of Biological Macromolecules
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
246
