Gram negatif bakteri üremesi olan üriner sistem enfeksiyonu tanılı olgularda monosit kemoatraktan protein-1 ve rantes gen polimorfizminin yeri ve genotip-fenotip ilişkisi
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Tarih
2016
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Yayıncı
Ege Üniversitesi, Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
İdrar yolu enfeksiyonu (İYE), çocuklarda sıktır. Konağa ve mikroorganizmaya ait faktörler İYE gelişimini etkiler. İYE patogenezinde, mikroorganizmaların tanınmalarını sağlayan doğal immün sistem önemli bir yer tutar. Doğal immun sistem, reseptör ve sinyal moleküllerinden oluşur. Monosit kemoatraktan protein 1 ve RANTES inflamatuar süreçte rol alan iki kemokindir. Bu çalışmanın amacı, İYE olan olgularda ve sağlıklı bireylerde RANTES-403 G>A, RANTES-28 C>G ve MCP-1-2518 A>G sıklıklarını inceleyerek, bu polimorfizmleri taşıyan hastaların İYE'na yatkın olup olmadıklarını değerlendirmektir. Çalışmaya, 104 İYE olan hasta ve 100 sağlıklı kontrol grubu dahil edildi. Her iki grubun cinsiyet dağılımları ve yaş ortalamaları benzerdi. Hasta grubunda en sık semptom ateş ve kusma idi. En sık üreyen mikroorganizmalar, E.coli (n=83; %79,8) ve Klebsiella pneumonia (n=11; %10,6) idi. 50 hasta (%48,1) üst İYE, 54 hasta (%51,1) alt İYE idi. Hasta ve kontrol gruplarında RANTES-403 G>A, RANTES -28 C>G polimorfizmleri benzer sıklıkta iken, MCP-1-2518A>G polimorfizmi sıklıkları farklı idi. Ancak, bu polimorfizm açsından üst ve alt İYE gruplarında fark saptanmadı. MCP-1-2518 için G alleli taşıyanlarda, İYE riski 2,3 kat artmış olarak bulundu (göreceli olasılıklar oranı (=odds ratio): 2,3 %95 güvenlik aralığı (CI):1,3-4,0; p=0,036).
Urinary tract infection (UTI) is frequent in children. Factors associated with host and microorganisms affect UTI. Innate immune system which recognizes microorganisms is important in the pathogenesis of UTI. Innate immun system consists of receptors and signal molecules. Monocyte chemoattractant protein-1 and RANTES are two chemokins acting in inflamatory processes. The aim of this study is to examine the frequency of RANTES-403 G>A, RANTES-28 C>G ve MCP-1-2518 A>G polymorphisms in patients with UTI and controls and to determine whether patients with these polymorphisms are prone to UTI. One hundred and four patients with UTI and 100 healthy subjects as contol group were included in this study. The frequency of gender and avarege of age were similar in both groups. Fever and vomiting were the most seen symptoms in patient group. The most frequent microorganisms were E.coli (n=83; %79,8) ve Klebsiella pneumonia (n=11; %10,6). Fifty were (%48,1) upper UTI, and 54 (%51,1) were lower UTI in patients group. Although the frequency of RANTES-403 G>A, RANTES -28 C>G polimorphisms were similar in both groups, MCP-1-2518A>G polimorphism was different in groups. But, the frequency of this polymorphism was similar in patients with upper and lower UTI. UTI risk was 2.3 times increased in patients having G allel in MCP-1-2518 (odds ratio: 2,3 % CI:1,3-4,0; p=0,036).
Urinary tract infection (UTI) is frequent in children. Factors associated with host and microorganisms affect UTI. Innate immune system which recognizes microorganisms is important in the pathogenesis of UTI. Innate immun system consists of receptors and signal molecules. Monocyte chemoattractant protein-1 and RANTES are two chemokins acting in inflamatory processes. The aim of this study is to examine the frequency of RANTES-403 G>A, RANTES-28 C>G ve MCP-1-2518 A>G polymorphisms in patients with UTI and controls and to determine whether patients with these polymorphisms are prone to UTI. One hundred and four patients with UTI and 100 healthy subjects as contol group were included in this study. The frequency of gender and avarege of age were similar in both groups. Fever and vomiting were the most seen symptoms in patient group. The most frequent microorganisms were E.coli (n=83; %79,8) ve Klebsiella pneumonia (n=11; %10,6). Fifty were (%48,1) upper UTI, and 54 (%51,1) were lower UTI in patients group. Although the frequency of RANTES-403 G>A, RANTES -28 C>G polimorphisms were similar in both groups, MCP-1-2518A>G polimorphism was different in groups. But, the frequency of this polymorphism was similar in patients with upper and lower UTI. UTI risk was 2.3 times increased in patients having G allel in MCP-1-2518 (odds ratio: 2,3 % CI:1,3-4,0; p=0,036).