Are human chorionic gonadotropin levels predictive for pregnancy outcome in assisted reproducditive techonology treatment cycles?
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Tarih
2002
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada ART sikluslarında ilk ölçülen HGG seviyesinin gebeliğin devamında belirleyici bir özellik olup olmadığı araştırılmıştır. Materyal ve Metod: ART uygulanan 127 hasta çalışmaya alındı. 40 yaş ve üzerindeki hastalar spontan abortus risklerinin artmış olması nedeniyle araştırmaya dahil edilmedi. Embryo transferi sonrası 12. günde hastalardan alman kanlarda hCG ve progesteron çalışıldı. Devam eden gebelikler ve kaybedilen olgular, hCG ve progesteron seviyelerine göre karşılaştırıldılar. Bulgular: Devam eden gebelik grubunda (n=68) ortalama yaş 32,8±4,6 iken, gebelik kaybı olan grupta (n59) 34,2±4,1 idi (p>0,05). Total hCG ve progesteron seviyeleri yönünden iki grup arasında anlamlı fark bulundu (J75,0±120,0 IU/L ve 39,9±55,5 IU/Lp=0,0001 ve 155,2±113,3 ng/ml ve 74,05+85,5 ng/rnl p= 0,03). Sonuç: Embryo transferi sonrası 12 gün ölçülen tek hCG seviyesi ile gebelik prognozu tahmin edilebilir. Bu suretle klinik prognoz hakkında hastayı ve aileyi bilgilendirmek mümkün görünmektedir.
Objective: The objective of this study was to find a reliable prognostic marker for the outcome of pregnancies in assisted reproductive technology (ART) cycles. Institution: Ege University Family Planning, Infertility Research and Treatment Center, Izmir, Turkey Study Design: One hundred and twenty seven patients who had undergone in vitro fertilization and embryo transfer were enrolled into the study. Forty years and older patients were not included in the study because the worse effect of the age on spontaneous pregnancy loss. Multiple pregnancies which were detected on the first ultrasonography were also excluded. Serum collected 12 days after embryo transfer following any of above ART cycles and was assayed for human chorionic gonadotropin (hCG) and progesterone levels with automated system. The ongoing pregnancies and miscarriages were computed with regard to hCG and progesterone levels. Results: The mean age of the patients in ongoing pregnancy group (n=68) was 32.8±4.9 and in the miscarriage group (n59) was 34.2+4.1 years (p>0.05). Total hCG and progesterone levels were found to be significantly different between ongoing pregnancy and miscarriage groups ( 17'5.0± 120.0 IU/L and 39.9±55.5 IU/L, p=0.0001 versus 155.2±113.3 ng/mL and 74.05±85.5 ng/mL, p=0.03). Conclusion: In conclusion, a single serum sample taken for hCG levels is useful in predicting pregnancy outcome. By measuring hCG level, valuable information could be inferred about the clinical prognosis in a critical period for the patient and her family.
Objective: The objective of this study was to find a reliable prognostic marker for the outcome of pregnancies in assisted reproductive technology (ART) cycles. Institution: Ege University Family Planning, Infertility Research and Treatment Center, Izmir, Turkey Study Design: One hundred and twenty seven patients who had undergone in vitro fertilization and embryo transfer were enrolled into the study. Forty years and older patients were not included in the study because the worse effect of the age on spontaneous pregnancy loss. Multiple pregnancies which were detected on the first ultrasonography were also excluded. Serum collected 12 days after embryo transfer following any of above ART cycles and was assayed for human chorionic gonadotropin (hCG) and progesterone levels with automated system. The ongoing pregnancies and miscarriages were computed with regard to hCG and progesterone levels. Results: The mean age of the patients in ongoing pregnancy group (n=68) was 32.8±4.9 and in the miscarriage group (n59) was 34.2+4.1 years (p>0.05). Total hCG and progesterone levels were found to be significantly different between ongoing pregnancy and miscarriage groups ( 17'5.0± 120.0 IU/L and 39.9±55.5 IU/L, p=0.0001 versus 155.2±113.3 ng/mL and 74.05±85.5 ng/mL, p=0.03). Conclusion: In conclusion, a single serum sample taken for hCG levels is useful in predicting pregnancy outcome. By measuring hCG level, valuable information could be inferred about the clinical prognosis in a critical period for the patient and her family.
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Kaynak
Türk Fertilite Dergisi
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Cilt
10
Sayı
4
