Synthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalation

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dc.authoridKARAER TUNCAY, ASLIHAN/0000-0003-4830-1964
dc.authoridatmaca, harika/0000-0002-8459-4373
dc.authoridturkmen, hayati/0000-0001-7411-2652
dc.authoridILHAN, Suleyman/0000-0002-6584-3979
dc.contributor.authorKarabiyik, Hande
dc.contributor.authorTuncay, Aslihan Karaer
dc.contributor.authorIlhan, Suleyman
dc.contributor.authorAtmaca, Harika
dc.contributor.authorTurkmen, Hayati
dc.date.accessioned2024-08-31T07:50:16Z
dc.date.available2024-08-31T07:50:16Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractA series of aryl-isatin Schiff base derivatives (3a-d) and their piano-stool ruthenium complexes (4a-d) were synthesized and characterized via H-1 and C-13 NMR and Fourier transform infrared (FTIR) spectroscopy. In addition, the purity of all of the compounds (3a-c and 4a-d) was determined via elemental analysis. Complex 4d was analyzed using X-ray crystallography. An in vitro antiproliferative study of the compounds (3a-c and 4a-d) against human hepatocellular carcinoma (HEPG2), human breast cancer (MCF-7), human prostate cancer (PC-3), and human embryonic kidney (HEK-293) cells exhibited their considerable antiproliferative activity. 4d exhibited effective cytotoxicity against HEPG2 and MCF-7. It displayed higher cytotoxicity than the reference metallo-drug cisplatin. Moreover, the stability of 4d was studied via 1H NMR spectroscopy, and the binding model between 4d and DNA was investigated via ultraviolet-visible spectroscopy. The lipophilicity of the synthesized complexes was determined using an extraction method.en_US
dc.description.sponsorshipEge University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentationen_US
dc.description.sponsorshipThe authors are grateful to Ege University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentation for their support in editing and proofreading service of this study.en_US
dc.identifier.doi10.1021/acsomega.3c10265
dc.identifier.endpage19147en_US
dc.identifier.issn2470-1343
dc.identifier.issue17en_US
dc.identifier.pmid38708280en_US
dc.identifier.scopus2-s2.0-85190738743en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage19136en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c10265
dc.identifier.urihttps://hdl.handle.net/11454/105179
dc.identifier.volume9en_US
dc.identifier.wosWOS:001204950100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectRuthenium Anticancer Compoundsen_US
dc.subjectCancer-Therapyen_US
dc.subjectCo(Ii)en_US
dc.subjectLiganden_US
dc.subjectMetalen_US
dc.titleSynthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalationen_US
dc.typeArticleen_US

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