Demonstration of glycine peaks at 3.50 ppm in a patient with van der Knaap Syndrome
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Soc Neuroradiology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Elevated levels of glycine in the CSF have recently been documented in van der Knaap syndrome (diffuse leukoencephalopathy associated with cystic degeneration of the white matter). This report describes a patient affected with the syndrome in whom proton NIR spectroscopy showed probable glycine peaks at 3.50 ppm in the brain parenchyma. An experimental study with a superconducting 9.397-T laboratory spectrometer identified the location of pure glycine at 3.52 ppm, originating from the methylene (CH2) group of the molecule. This suggests that the peak at 3.50 ppm in patients with van der Knaap syndrome may belong to glycine, as a slight shift in peak resonances is possible as a result of spatial electron interactions.
Açıklama
Anahtar Kelimeler
Kaynak
American Journal of Neuroradiology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
22
Sayı
8
