Synthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivatives

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dc.contributor.authorAkgül, Özlem
dc.contributor.authorTarıkoğulları, Ayşe Hande
dc.contributor.authorKöse, Fadime Aydnın
dc.contributor.authorKırmızıbayrak, Petek Ballar
dc.contributor.authorPabuççuoğlu, Mehmet Varol
dc.date.accessioned2020-12-01T12:23:14Z
dc.date.available2020-12-01T12:23:14Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIsatin, 1H -indoline-2,3-dione, an endogenous compound, is also a synthetically versatile molecule that possesses a diversity of biological activities including anticonvulsant, antibacterial, antifungal, antiviral, anticancer, and cytotoxic properties. Based on the promising cytotoxic activity studies on N -substituted isatin derivatives, a series of 18 derivatives of 2-(2,3-dioxo-2,3-dihydro-1H -indol-1-yl)-N-phenylacetamide were designed, synthesized, and characterized according to their analytical and spectral data. All of the compounds were evaluated for their cytotoxic activity against MCF7, A549, HeLa, and HEK293 cell lines by real time cell analyzer. Etoposide was used as a standard compound. Briefly, ortho substitutions gave better results compared to meta and para substitutions on the N−phenyl ring and compounds bearing ortho substitutions were more effective on MCF7 cell lines than A549 and HeLa cell lines. 2-(2,3- Dioxo-2,3-dihydro-1H -indol-1-yl)-N-(2-isopropylphenyl)acetamide was the most active compound against all the tested cell lines.en_US
dc.identifier.endpage212en_US
dc.identifier.issn1300-0527
dc.identifier.issn1303-6130
dc.identifier.issue2en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TVRRMk1UazBOQT09
dc.identifier.urihttps://hdl.handle.net/11454/65175
dc.identifier.volume37en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMühendislik, Kimyaen_US
dc.titleSynthesis and cytotoxic activity of some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide derivativesen_US
dc.typeArticleen_US

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