Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats

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dc.contributor.authorKuralay, F
dc.contributor.authorYildiz, C
dc.contributor.authorOzutemiz, O
dc.contributor.authorIslekel, H
dc.contributor.authorCaliskan, S
dc.contributor.authorBingol, B
dc.contributor.authorOzkal, S
dc.date.accessioned2019-10-27T19:02:00Z
dc.date.available2019-10-27T19:02:00Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractInduction of colitis by acetic acid (AA) in the rat is widely used experimental model of inflammatory bowel disease (IBD) and ulcerations. AA as an irritant induces colitis involving infiltration of colonic mucosa with neutrophils and increased production of inflammatory mediators, such as hydrogen peroxide (H2O2), nitric oxide (NO), myeloperoxiclase activity (MPO), and tumor necrosis factor (TNF-alpha). Trimetazidine (TMZ), an antianginal compound, was administered to investigate if its cytoprotective features in cardiac tissue are also effective in AA colitis where ischemic injury contributes to colitis. Administration of TMZ intraperitoneally improved the macroscopic and microscopic score alterations produced by AA, AA administration significantly elevated colonic MPO activity; however, treatment with TMZ significantly lowered this enzyme activity compared to AA. AA administration significantly enhanced superoxide dismutase (SOD) activities, except for A/A + TMZ given rectally, TMZ treatment significantly, lowered nitrate levels, but AA increased these levels. AA administration markedly lowered TNF-alpha levels, but TMZ treatment elevated these levels to control. These findings indicate that overproduction of NO may be involved in the immunosuppression observed during acute AA-induced rat colitis, In conclusion, TMZ treatment was more effective via the intraperitoneal than rectal route, and may be beneficial in therapy of colitis.en_US
dc.identifier.doi10.1080/15287390390155822en_US
dc.identifier.endpage179en_US
dc.identifier.issn1528-7394
dc.identifier.issue2en_US
dc.identifier.pmid12653021en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.1080/15287390390155822
dc.identifier.urihttps://hdl.handle.net/11454/37960
dc.identifier.volume66en_US
dc.identifier.wosWOS:000180646700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Toxicology and Environmental Health-Part Aen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of trimetazidine on acetic acid-induced colitis in female Swiss ratsen_US
dc.typeArticleen_US

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