In vivo interaction between cadmium and essential trace elements copper and zinc in rats

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dc.contributor.authorHakan Aydin H.
dc.contributor.authorÇoker C.
dc.contributor.authorErsöz B.
dc.date.accessioned2019-10-27T00:25:25Z
dc.date.available2019-10-27T00:25:25Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractThe complex in vivo interaction between Cd, a toxic metal and essential trace elements, mainly Zn and Cu, has not been elucidated yet. The objective being the elucidation of this interrelationship, Cd was subcutaneously administered as CdCl2 (1 mg/kg/day) for 5 consecutive days to Swiss albino male rats (n=10). After 5 days, the rats were decapitated. Cd, Zn and Cu levels were estimated in hepatic, renal, cardiac and skeletal muscle specimens. Cd was found to be significantly elevated in all tissues (p< 0.001). Zn was increased in hepatic and renal tissues (p< 0.001 and p< 0.05) compared to the controls. Cu was also significantly increased in these tissues. Myocardial and skeletal muscle tissues also manifested a significant increase in Cu and Zn in this group. It is concluded that Cd administration alters the Zn and Cu status in vivo. However, the mechanism underlying the interactions between toxic and essential elements should be further investigated.en_US
dc.identifier.endpage129en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://hdl.handle.net/11454/23246
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCadmiumen_US
dc.subjectCopperen_US
dc.subjectMetallothioneinen_US
dc.subjectZincen_US
dc.titleIn vivo interaction between cadmium and essential trace elements copper and zinc in ratsen_US
dc.typeArticleen_US

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