Latent ve aktif tüberkülozu olan hastalarda tüberkülin deri testi ile quantiFERON-TB testinin karşılaştırılması
Küçük Resim Yok
Tarih
2006
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tüberkülin deri testi, latent tüberküloz infeksiyonun tanısında yıllardır kullanılmaktadır. Bu çalışmada, aktif ve latent tüberkülozlu kişilerde tüberkülin deri testi ile QuantiFERON-TB testinin etkinliğini araştırmak amaçlanmıştır. Elli üç kişi değerlendirmeye alınmıştır. Grup I, primer aktif tüberkülozlu 21 hastadan oluşmaktadır. Grup II tüberkülin deri testi pozitif olan (TDT>15 mm) 20 kişiden ve Grup III ise tüberkülin deri testi negatif (TDT< 5 mm) olan 11 kişiden oluşmaktadır. Hastaların tümüne tüberkülin deri testi ve QuantiFERON-TB testi uygulanmıştır. Grup I'de QuantiFERON-TB testi ile yedi hasta pozitif, iki hasta negatif olarak bulunmuş ve 12 hastada mitojen uyarımı izlenmemiştir. QuantiFERON-TB testi Grup II'deki hastaların biri hariç tümünde pozitif, Grup III'deki hastaların biri hariç tümünde de negatif bulunmuştur. QuantiFERON-TB testinin aktif tüberkülozlu hastaların çoğunluğunda mitojen uyarımı olmaması nedeniyle başarısız olduğu izlenmiştir. Ancak latent tüberkülozu olan ve tüberkülin deri testi negatif olan kişilerde QuantiFERON-TB testi sonuçları TDT ile eşdeğer bulunmuştur.
Tuberculin skin test has been used for many years for the diagnosis of latent tuberculosis infection. The aim of this study was to compare the effectiveness of tuberculin skin test (TST) and QuantiFERON-TB (QFT) in diagnosing latent and active tuberculosis. A total of 53 patients were evaluated in this study. Group I consisted of 21 patients with primary active tuberculosis. Group II consisted of 20 patients who were TST positive (TST>15mm) and Group III consisted of 12 patients who were TST negative (TST<5 mm). TST and QFT were applied to all patients. The QFT test showed positive result in seven, negative in two and no mitogen stimulus in 12 of patients with active tuberculosis (Group I). In Group II, all patients but one showed positive QFT test. QFT test was found as negative in 11 of 12 patients with TST negative (Group III). The QFT test was of no use in the majority of patients with active tuberculosis as they failed to demonstrate mitogen stimulus. However, in other patients, the QFT test results were found to be comparable with TST.
Tuberculin skin test has been used for many years for the diagnosis of latent tuberculosis infection. The aim of this study was to compare the effectiveness of tuberculin skin test (TST) and QuantiFERON-TB (QFT) in diagnosing latent and active tuberculosis. A total of 53 patients were evaluated in this study. Group I consisted of 21 patients with primary active tuberculosis. Group II consisted of 20 patients who were TST positive (TST>15mm) and Group III consisted of 12 patients who were TST negative (TST<5 mm). TST and QFT were applied to all patients. The QFT test showed positive result in seven, negative in two and no mitogen stimulus in 12 of patients with active tuberculosis (Group I). In Group II, all patients but one showed positive QFT test. QFT test was found as negative in 11 of 12 patients with TST negative (Group III). The QFT test was of no use in the majority of patients with active tuberculosis as they failed to demonstrate mitogen stimulus. However, in other patients, the QFT test results were found to be comparable with TST.
Açıklama
Anahtar Kelimeler
Enfeksiyon Hastalıkları
Kaynak
İnfeksiyon Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
20
Sayı
1
